Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate.
Reflections on the cost of "low-cost" whole genome sequencing: framing the health policy debate.
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DOI：
10.1371/journal.pbio.1001699
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发表时间：
2013-11
期刊：
影响因子：
9.8
通讯作者：
Wilson B
中科院分区：
文献类型：
--
作者：
Caulfield T;Evans J;McGuire A;McCabe C;Bubela T;Cook-Deegan R;Fishman J;Hogarth S;Miller FA;Ravitsky V;Biesecker B;Borry P;Cho MK;Carroll JC;Etchegary H;Joly Y;Kato K;Lee SS;Rothenberg K;Sankar P;Szego MJ;Ossorio P;Pullman D;Rousseau F;Ungar WJ;Wilson B
整个基因组测序的未来临床应用具有猜测和热情，但需要仔细考虑这种令人兴奋的技术的临床用途的真实系统成本和健康益处。
整个基因组测序的成本正在迅速下降。人们对这种技术进步改变临床护理的潜力充满热情。鉴于对基因组学的兴趣和大量投资，这似乎是考虑证据告诉我们潜在益处的理想时机，尤其是在医疗保健政策的背景下。这种强大的新技术的采用规模和步伐应由临床需求，临床证据以及将患者置于卫生保健政策中心的承诺。
The future clinical applications of whole genome sequencing come with speculation and enthusiasm but require careful consideration of the true system costs and health benefits of the clinical uses of this exciting technology. The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us about potential benefits and harms, particularly in the context of health care policy. The scale and pace of adoption of this powerful new technology should be driven by clinical need, clinical evidence, and a commitment to put patients at the centre of health care policy.
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DOI：
10.1038/gim.2013.11
发表时间：
2013-05
期刊：
Genetics in medicine : official journal of the American College of Medical Genetics
影响因子：
--
作者：
Evans JP;Berg JS;Olshan AF;Magnuson T;Rimer BK
通讯作者：
Rimer BK
影响因子：
1.7
作者：
Caulfield, T.;Condit, C.
通讯作者：
Condit, C.
影响因子：
12.3
作者：
Caulfield, Timothy;Chandrasekharan, Subhashini;Cook-Deegan, Robert
通讯作者：
Cook-Deegan, Robert
DOI：
10.1056/nejmoa1011893
发表时间：
2011-02-10
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bloss CS;Schork NJ;Topol EJ
通讯作者：
Topol EJ
影响因子：
17.1
作者：
Bainbridge MN;Wiszniewski W;Murdock DR;Friedman J;Gonzaga-Jauregui C;Newsham I;Reid JG;Fink JK;Morgan MB;Gingras MC;Muzny DM;Hoang LD;Yousaf S;Lupski JR;Gibbs RA
通讯作者：
Gibbs RA