Chromosome Fusion Affects Genetic Diversity and Evolutionary Turnover of Functional Loci but Consistently Depends on Chromosome Size.
Chromosome Fusion Affects Genetic Diversity and Evolutionary Turnover of Functional Loci but Consistently Depends on Chromosome Size.
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DOI：
10.1093/molbev/msab185
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发表时间：
2021-09-27
影响因子：
10.7
通讯作者：
Montgomery SH
中科院分区：
文献类型：
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作者：
Cicconardi F;Lewis JJ;Martin SH;Reed RD;Danko CG;Montgomery SH
染色体数量和结构的重大变化与一系列进化现象有关，包括基因流动的内在障碍或由于染色体重排而抑制重组。然而，染色体重排也可以通过改变连锁基因座之间的关系和改变重组率来影响群体内分子进化的基本动力学。在这里，我们建立染色体水平组装Eueides isabella，连同最近的染色体水平组装的Dryas iulia，研究多个染色体融合的进化后果Heliconius蝴蝶。这些装配精确定位了20条常染色体中的10条上的融合点，并揭示了融合和未融合染色体特征的显著差异。D. iulia和E. isabella，每个都与Heliconius中较长染色体融合，具有较高的重复和GC含量，以及较长的内含子。当融合时，这些特征改变成与染色体长度更一致。融合还导致多样性降低，这可能反映了在每个碱基重组率降低之后，背景选择和针对不同群体之间的渐渗的选择增加。我们进一步表明，染色体大小和融合的影响周转率的功能位点在宏观进化尺度。总之，这些结果提供了进一步的证据表明，Heliconius的染色体融合可能有显着的影响，人口水平的过程塑造率的中性和适应性的分歧。这些效应可能影响了Heliconius的多样化模式，这是适应性辐射的一个典型例子。
Major changes in chromosome number and structure are linked to a series of evolutionary phenomena, including intrinsic barriers to gene flow or suppression of recombination due to chromosomal rearrangements. However, chromosome rearrangements can also affect the fundamental dynamics of molecular evolution within populations by changing relationships between linked loci and altering rates of recombination. Here, we build chromosome-level assembly Eueides isabella and, together with a recent chromosome-level assembly of Dryas iulia, examine the evolutionary consequences of multiple chromosome fusions in Heliconius butterflies. These assemblies pinpoint fusion points on 10 of the 20 autosomal chromosomes and reveal striking differences in the characteristics of fused and unfused chromosomes. The ten smallest autosomes in D. iulia and E. isabella, which have each fused to a longer chromosome in Heliconius, have higher repeat and GC content, and longer introns than predicted by their chromosome length. When fused, these characteristics change to become more in line with chromosome length. The fusions also led to reduced diversity, which likely reflects increased background selection and selection against introgression between diverging populations, following a reduction in per-base recombination rate. We further show that chromosome size and fusion impact turnover rates of functional loci at a macroevolutionary scale. Together these results provide further evidence that chromosome fusion in Heliconius likely had dramatic effects on population level processes shaping rates of neutral and adaptive divergence. These effects may have impacted patterns of diversification in Heliconius, a classic example of an adaptive radiation.
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DOI：
10.1534/g3.115.023655
发表时间：
2016-01-15
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Davey JW;Chouteau M;Barker SL;Maroja L;Baxter SW;Simpson F;Merrill RM;Joron M;Mallet J;Dasmahapatra KK;Jiggins CD
通讯作者：
Jiggins CD
DOI：
10.1016/j.cub.2017.08.038
发表时间：
2017-10-09
期刊：
Current biology : CB
影响因子：
--
作者：
Fradin H;Kiontke K;Zegar C;Gutwein M;Lucas J;Kovtun M;Corcoran DL;Baugh LR;Fitch DHA;Piano F;Gunsalus KC
通讯作者：
Gunsalus KC
影响因子：
3.3
作者：
Guerrero, Rafael F.;Kirkpatrick, Mark
通讯作者：
Kirkpatrick, Mark
影响因子：
9.8
作者：
Corbett-Detig RB;Hartl DL;Sackton TB
通讯作者：
Sackton TB
使用下一代 DNA 测序数据进行变异发现和基因分型的框架。
影响因子：
30.8
作者：
通讯作者：
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