Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance.
Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance.
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边缘前皮层而非边缘下皮层的失活会损害福尔马林诱导的条件性场所回避的获得和表达
DOI：
10.1016/j.neulet.2014.03.074
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发表时间：
2014-05-21
影响因子：
2.5
通讯作者：
Luo F
中科院分区：
文献类型：
--
作者：
Jiang ZC;Pan Q;Zheng C;Deng XF;Wang JY;Luo F
条件性位置回避（Conditioned place avoidance，CPA）范式已被用于研究疼痛的情感成分。虽然前扣带皮层（ACC）已被证明在疼痛的情感方面发挥了重要作用，其他前额叶分区是否参与疼痛相关的厌恶是未知的。本研究探讨了大鼠前边缘皮层（PL）和下边缘皮层（IL）在福尔马林诱导的CPA（F-CPA）获得和表达中的作用。在福尔马林配对训练前或训练后，将GABAA受体激动剂蝇蕈醇（muscimol）分别注入PL/IL，观察PL/IL暂时失活对F-CPA获得和表达的影响。结果表明，PL而不是IL的失活损害了F-CPA的获得和表达。此外，PL失活并没有阻止获得氯化锂诱导的CPA，这表明PL可能是具体涉及的疼痛情绪相关的编码。这些结果表明，PL，而不是IL参与了痛苦的厌恶维度。
Conditioned place avoidance (CPA) paradigm has been used to investigate the affective component of pain. Although the anterior cingulate cortex (ACC) has been demonstrated to play an important role in the affective aspect of pain, whether the other prefrontal subdivisions are involved in pain-related aversion is unknown. The present study investigated the role of the prelimbic cortex (PL) and infralimbic cortex (IL) in the acquisition and expression of formalin-induced CPA (F-CPA) in rats. GABAA receptor agonist muscimol was bilaterally microinjected into PL/IL before or after the formalin-paired training, to explore the effect of temporary inactivation of PL/IL on the acquisition and expression of F-CPA, respectively. The results showed that inactivation of PL rather than IL impaired the acquisition and expression of F-CPA. Moreover, the PL inactivation did not block the acquisition of LiCl-induced CPA, suggesting that PL may be specifically implicated in the pain-emotion related encoding. These results indicate that PL but not IL is involved in the aversive dimension of pain.
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