Stress-induced prefrontal reorganization and executive dysfunction in rodents.
Stress-induced prefrontal reorganization and executive dysfunction in rodents.
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DOI：
10.1016/j.neubiorev.2008.11.005
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发表时间：
2009-06
影响因子：
8.2
通讯作者：
Wellman, Cara L.
中科院分区：
文献类型：
--
作者：
Holmes, Andrew;Wellman, Cara L.
关键词：
前额叶皮层（PFC）介导一系列高阶“执行功能”，这些功能有助于信息的选择和处理，从而可以根据不断变化的环境需求来计划，控制和指导行为。执行功能受损是许多形式的精神病理学的典型，包括精神分裂症、情绪和焦虑障碍以及成瘾，这些往往与创伤和压力史有关。最近在动物模型中的研究表明，即使是短暂的强烈压力也足以引起啮齿动物PFC内主要投射神经元的显著结构重塑。同时，越来越多的证据表明，压力诱导的PFC神经元形态学改变与啮齿动物执行功能如工作记忆，注意力转移和认知灵活性的缺陷有关。以及以恐惧消退受损的形式出现的情绪失调。虽然压力诱导的PFC形态和功能变化的分子基础现在才被阐明，这些机制的理解可以提供重要的洞察神经精神疾病的执行功能障碍的病理生理学，并促进改善治疗策略。
The prefrontal cortex (PFC) mediates a range of higher order ‘executive functions’ that subserve the selection and processing of information in such a way that behavior can be planned, controlled and directed according to shifting environmental demands. Impairment of executive functions typifies many forms of psychopathology, including schizophrenia, mood and anxiety disorders and addiction, that are often associated with a history of trauma and stress. Recent research in animal models demonstrates that exposure to even brief periods of intense stress is sufficient to cause significant structural remodeling of the principle projection neurons within the rodent PFC. In parallel, there is growing evidence that stress-induced alterations in PFC neuronal morphology are associated with deficits in rodent executive functions such as working memory, attentional set-shifting and cognitive flexibility, as well as emotional dysregulation in the form of impaired fear extinction. Although the molecular basis of stress-induced changes in PFC morphology and function are only now being elucidated, an understanding of these mechanisms could provide important insight into the pathophysiology of executive dysfunction in neuropsychiatric disease and foster improved strategies for treatment.
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影响因子：
3.8
作者：
CASSELL, MD;WRIGHT, DJ
通讯作者：
WRIGHT, DJ
影响因子：
3.1
作者：
Akirav I;Maroun M
通讯作者：
Maroun M
DOI：
10.1080/10253890290027895
发表时间：
2002-01-01
影响因子：
2.3
作者：
Campeau, Serge;Dolan, David;Watson, Stanley J., Jr.
通讯作者：
Watson, Stanley J., Jr.
影响因子：
3.6
作者：
ANISMAN, H;HAHN, B;ZACHARKO, RM
通讯作者：
ZACHARKO, RM
影响因子：
3.3
作者：
Amat, J.;Paul, E.;Maier, S. F.
通讯作者：
Maier, S. F.