Intravenous endothelin-1 triggers pulmonary hypertension syndrome (ascites) in broilers
Intravenous endothelin-1 triggers pulmonary hypertension syndrome (ascites) in broilers
复制标题
静脉注射内皮素-1 引发肉鸡肺动脉高压综合征（腹水）
DOI：
10.17221/1989-vetmed
复制
发表时间：
2018-02
影响因子：
0.746
通讯作者：
Zhou, D. H.
中科院分区：
文献类型：
--
作者：
Cheng, D. C.;Yang, S. J.;Wu, J.;Guo, D. Z.;Zhou, D. H.
本试验通过两个试验研究了内皮素-1(ET-1)对肉鸡肺动脉压(PAP)和肺动脉高压综合征(PHS、腹水)发病率的影响。将270只1日龄AA肉鸡随机分为两组，每组10只。试验一，40只28日龄肉鸡静脉注射5种不同剂量的ET-1，测定0~30min的PAP。结果表明，注射24 ng/kg(T1组)、120 ng/kg(T2组)、240 ng/kg(T3组)ET-1后0.5~5min，PAP升高；给肉鸡注射360 ng/kg的ET-1(T4组)后，0~0.5min的PAP显著降低，0.5~10min的PAP显著升高。比较4组治疗前后PAP的变化，并与对照组(C组)进行比较。经统计学分析，T1、T2组与对照组(C组)比较，差异无统计学意义(P>0.05)。但T3、T4组与对照组(C组)比较，差异有统计学意义。试验2选用230只肉鸡，随机分为4组：对照组(C组，n=50)和3个试验组(A、B、D组)。A、B两组各60只，分别以240 ng/kg和360 ng/kg的剂量静脉注射ET-1。D组(n=60)暴露于10℃~14℃的低温环境中。记录两组PHS发生率、右室/总室重(RV/TV)、PCV、血浆一氧化氮(NO)、PAP，并进行统计学比较。结果显示，C组无PHS死亡，A、B、D组PHS死亡率上升趋势不明显。A、B、D组的RV/TV比值和PAP均高于C组，PCV和血浆一氧化氮(NO)的变化趋势与RV/TV比值一致。结果表明，较高剂量(240~360 ng/kg)的ET-1可引起肉鸡肺动脉高压和右室肥厚，导致PHS。
Two experiments were conducted to evaluate the effect of endothelin-1(ET-1) on pulmonary arterial pressure (PAP) and pulmonary hypertension syndrome (PHS, ascites) morbidity in broilers. Two hundred and seventy of one-day-old Arbor Acre commercial broiler chickens were randomly allocated into two experiments. In Experiment 1, 40 broilers (28 days of age) were intravenously with five different dose groups of ET-1, and the PAP was measured from time 0 to 30 min. The results indicated that the PAP increased from time 0.5 to 5 min after the broilers were injected with ET-1 at concentrations of 24 ng/kg (Group T1), 120 ng/kg (Group T2), and 240 ng/kg (Group T3). When the broilers were injected with ET-1 at a concentration of 360 ng/kg (Group T4), the PAP decreased immediately from time 0 to 0.5 min but increased from time 0.5 to 10 min. The change from baseline (at time 0, before the injection) of PAP values from the four treatment groups were statistically compared with that from the control group (Group C). The statistical analysis has demonstrated that there is no significant difference of the changes from the baseline between Group T1 or Group T2 and control group (Group C). How- ever, there are significant differences in the changes between Group T3 or Group T4 and control group (Group C). In Experiment 2, 230 broilers were divided into four groups: a control group (Group C, n = 50) and three treat - ment groups (Groups A, B, and D). The chickens in the two treatment groups (Groups A and B, n = 60 each) were intravenously injected with ET-1 at 240 ng/kg and 360 ng/kg, respectively. Those in Group D ( n = 60) were exposed to cool temperatures (10°C to 14°C). The PHS morbidity, right/total ventricular weight (RV/TV) ratio, PCV, plasma nitric oxide (NO), and PAP were recorded and statistically compared. The results showed that PHS mortality did not occur in Group C, and trends toward increases in PHS mortality in Groups A, B and D were not significant. The RV/TV ratio and PAP were higher in groups A, B and D than in group C. The values for PCV and plasma nitric oxide (NO) followed the same tendencies as the RV/TV ratio. The results suggest that ET-1 at higher doses (240 ng/kg to 360 ng/kg) can initiate pulmonary hypertension and right ventricular hypertrophy, leading to PHS in broilers.
登录
查看更多内容
影响因子：
37.8
作者：
A. Lerman;F. Hildebrand;L. Aarhus;J. Burnett
通讯作者：
A. Lerman;F. Hildebrand;L. Aarhus;J. Burnett
影响因子：
1
作者：
Mirsalimi Sm;P. O'Brien;R. Julian
通讯作者：
Mirsalimi Sm;P. O'Brien;R. Julian
影响因子：
2.4
作者：
X. Tan;Jia-qiang Pan;Jin-chun Li;Yan-juan Liu;Wei-dong Sun;Xiao-long Wang
通讯作者：
X. Tan;Jia-qiang Pan;Jin-chun Li;Yan-juan Liu;Wei-dong Sun;Xiao-long Wang
DOI：
10.1016/0002-9149(93)90452-i
发表时间：
1993-02
期刊：
The American journal of cardiology
影响因子：
--
作者：
P. Cacoub;R. Dorent;G. Maistre;P. Nataf;A. Carayon;C. Piette;P. Godeau;C. Cabrol;I. Gandjbakhch
通讯作者：
P. Cacoub;R. Dorent;G. Maistre;P. Nataf;A. Carayon;C. Piette;P. Godeau;C. Cabrol;I. Gandjbakhch
影响因子：
2.8
作者：
JULIAN, RJ
通讯作者：
JULIAN, RJ