Angiographic Pulse Wave Coherence in the Human Brain.
Angiographic Pulse Wave Coherence in the Human Brain.
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DOI：
10.3389/fbioe.2022.873530
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发表时间：
2022
影响因子：
5.7
通讯作者：
Butler, William E.
中科院分区：
文献类型：
--
作者：
Koch, Matthew J.;Duy, Phan Q.;Grannan, Benjamin L.;Patel, Aman B.;Raymond, Scott B.;Agarwalla, Pankaj K.;Kahle, Kristopher T.;Butler, William E.
到达容纳在刚性颅骨中的大脑的动脉血的每搏输出量必须在心动周期上与喷射的静脉血的等效体积相匹配。我们假设大脑通过组织连贯的动脉和静脉脉搏波来维持这种平衡。为了验证这一假设，我们应用小波计算方法诊断脑血管造影在四个人类患者，允许捕获和分析的心脏频率的现象，从荧光透视图像采集速度比心率。我们发现，心脏频率倒数相位的一个小区域的利益（ROI）在一个指定的动脉预测静脉解剖像素的方式和预测的像素重建静脉团通过定时。同样，命名静脉中的小ROI预测动脉解剖结构和动脉推注通过时间。预测的动脉和静脉像素组在团行程上保持相位互补。因此，我们建立了一种新的计算方法来分析血管脉搏波微创脑血管造影，并提供了第一个直接证据的动静脉耦合在完整的人脑。这种动静脉耦合现象可能是大脑如何精确地保持机械平衡以对抗由每次心跳的周期性变形引起的体积位移和动能转移的生理机制。这项研究也为研究混乱的动静脉偶联作为一种未被充分认识的病理生理障碍，在无数的神经病理学与机械不平衡。
A stroke volume of arterial blood that arrives to the brain housed in the rigid cranium must be matched over the cardiac cycle by an equivalent volume of ejected venous blood. We hypothesize that the brain maintains this equilibrium by organizing coherent arterial and venous pulse waves. To test this hypothesis, we applied wavelet computational methods to diagnostic cerebral angiograms in four human patients, permitting the capture and analysis of cardiac frequency phenomena from fluoroscopic images acquired at faster than cardiac rate. We found that the cardiac frequency reciprocal phase of a small region of interest (ROI) in a named artery predicts venous anatomy pixel-wise and that the predicted pixels reconstitute venous bolus passage timing. Likewise, a small ROI in a named vein predicts arterial anatomy and arterial bolus passage timing. The predicted arterial and venous pixel groups maintain phase complementarity across the bolus travel. We thus establish a novel computational method to analyze vascular pulse waves from minimally invasive cerebral angiograms and provide the first direct evidence of arteriovenous coupling in the intact human brain. This phenomenon of arteriovenous coupling may be a physiologic mechanism for how the brain precisely maintains mechanical equilibrium against volume displacement and kinetic energy transfer resulting from cyclical deformations with each heartbeat. The study also paves the way to study deranged arteriovenous coupling as an underappreciated pathophysiologic disturbance in a myriad of neurological pathologies linked by mechanical disequilibrium.
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影响因子：
3.8
作者：
Kachelriess, M;Ulzheimer, S;Kalender, WA
通讯作者：
Kalender, WA
影响因子：
3.7
作者：
Butler, William E.;Agarwalla, Pankaj K.;Codd, Patrick
通讯作者：
Codd, Patrick
影响因子：
3.5
作者：
Goriely A;Geers MG;Holzapfel GA;Jayamohan J;Jérusalem A;Sivaloganathan S;Squier W;van Dommelen JA;Waters S;Kuhl E
通讯作者：
Kuhl E
DOI：
10.3390/life11060537
发表时间：
2021-06-09
期刊：
Life (Basel, Switzerland)
影响因子：
--
作者：
Eide PK
通讯作者：
Eide PK
影响因子：
3.7
作者：
Butler WE
通讯作者：
Butler WE