Viruses Strive to Suppress Host Immune Responses and Prolong Persistence
Viruses Strive to Suppress Host Immune Responses and Prolong Persistence
复制标题
病毒努力抑制宿主免疫反应并延长持续时间
作者：
C. Pritzl;Y. Seo;B. Hahm
Viruses regulate host immune responses to propagate their progeny. Indeed, certain viruses successfully establish viral persistence for long periods of time even in the immunocompetent host. Many viruses seem to have developed clever tactics to elude, utilize, or suppress host innate and adaptive immune systems. Unlike the parental strain, the clone 13 (Cl 13) strain of lymphocytic choriomeningitis virus (LCMV) has been shown to persist in mice for 60 – 100 days by nullifying the function of the host immune system. Multiple findings obtained from this mouse model have held true in humans chronically infected with viruses including human immunodeficiency virus (HIV) and hepatitis viruses. These viruses have evolved a repertoire of mechanisms to suppress and evade the host immune system. By utilizing the model for the LCMV infection of mice, this review will focus on the viral mechanisms for inhibition or escape of host immunity, in particular the host dendritic cell (DC) and T cell responses. Investigating the viral strategies will help us better understand the virus-host interplay and design new immunotherapeutic approaches.
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