A high-coverage genome sequence from an archaic Denisovan individual.

A high-coverage genome sequence from an archaic Denisovan individual.
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DOI:
10.1126/science.1224344
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发表时间:
2012-10-12
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Pääbo S
Pääbo S
中科院分区:
其他
文献类型:
--
作者:
Meyer M;Kircher M;Gansauge MT;Li H;Racimo F;Mallick S;Schraiber JG;Jay F;Prüfer K;de Filippo C;Sudmant PH;Alkan C;Fu Q;Do R;Rohland N;Tandon A;Siebauer M;Green RE;Bryc K;Briggs AW;Stenzel U;Dabney J;Shendure J;Kitzman J;Hammer MF;Shunkov MV;Derevianko AP;Patterson N;Andrés AM;Eichler EE;Slatkin M;Reich D;Kelso J;Pääbo S

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我们提出了一种DNA文库制备方法,该方法使我们能够重建丹尼索瓦人的高覆盖度(30倍)基因组序列,丹尼索瓦人是尼安德特人的一种已灭绝的近亲。这个基因组的质量允许直接估算丹尼索瓦人的杂合性,这表明这些古老的原始人类的遗传多样性极低。它还允许根据其基因组中的“缺失进化”对标本进行初步的年代测定,详细测量丹尼索瓦人和尼安德特人混入当今人类群体的情况,并生成一份自现代人类与丹尼索瓦人分化以来在现代人类中高频出现的遗传变化的近乎完整的目录。
We present a DNA library preparation method that has allowed us to reconstruct a high coverage (30X) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality of this genome allows a direct estimation of Denisovan heterozygosity indicating that genetic diversity in these archaic hominins was extremely low. It also allows tentative dating of the specimen on the basis of “missing evolution” in its genome, detailed measurements of Denisovan and Neandertal admixture into present-day human populations, and the generation of a near-complete catalog of genetic changes that swept to high frequency in modern humans since their divergence from Denisovans.
DOI: 10.1038/nature10231
发表时间: 2011-07-13
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影响因子: 64.8
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