SCOPe: Structural Classification of Proteins--extended, integrating SCOP and ASTRAL data and classification of new structures.
SCOPe: Structural Classification of Proteins--extended, integrating SCOP and ASTRAL data and classification of new structures.
复制标题
DOI：
10.1093/nar/gkt1240
复制
发表时间：
2014-01
影响因子：
14.9
通讯作者：
Chandonia JM
中科院分区：
文献类型：
--
作者：
Fox NK;Brenner SE;Chandonia JM
蛋白质结构分类扩展（SCOPe, http://scop.berkeley.edu）是扩展SCOP数据库的蛋白质结构关系数据库。SCOP是根据结构和进化关系对大多数已知结构的蛋白质的结构域进行人工排序。工作范围计划的发展x系列的SCOP为1.75。ASTRAL纲要提供了几个数据库和工具来帮助分析SCOP分类的蛋白质结构，特别是通过使用它们的序列。SCOPe扩展了1.75版本的SCOP数据库，使用自动管理方法对SCOP 1.75以来发布的许多结构进行分类。我们已经对我们的自动化方法进行了严格的基准测试，以确保它们与人工培养一样准确，尽管有许多蛋白质我们的方法不能应用。范围也是部分手动策划的，以纠正SCOP中的一些错误。SCOPe的目标是向后兼容SCOP，提供相同的可解析文件和所有稳定的SCOP和SCOPe版本之间的变更历史。SCOPe还合并并更新ASTRAL数据库。SCOPe的最新版本2.03包含59514个蛋白质数据库（PDB）条目，将SCOP分类的结构数量增加了55%，PDB中包含了65%以上的蛋白质结构。
Structural Classification of Proteins—extended (SCOPe, http://scop.berkeley.edu) is a database of protein structural relationships that extends the SCOP database. SCOP is a manually curated ordering of domains from the majority of proteins of known structure in a hierarchy according to structural and evolutionary relationships. Development of the SCOP 1.x series concluded with SCOP 1.75. The ASTRAL compendium provides several databases and tools to aid in the analysis of the protein structures classified in SCOP, particularly through the use of their sequences. SCOPe extends version 1.75 of the SCOP database, using automated curation methods to classify many structures released since SCOP 1.75. We have rigorously benchmarked our automated methods to ensure that they are as accurate as manual curation, though there are many proteins to which our methods cannot be applied. SCOPe is also partially manually curated to correct some errors in SCOP. SCOPe aims to be backward compatible with SCOP, providing the same parseable files and a history of changes between all stable SCOP and SCOPe releases. SCOPe also incorporates and updates the ASTRAL database. The latest release of SCOPe, 2.03, contains 59 514 Protein Data Bank (PDB) entries, increasing the number of structures classified in SCOP by 55% and including more than 65% of the protein structures in the PDB.
登录
查看更多内容
影响因子：
14.9
作者：
Wilson D;Pethica R;Zhou Y;Talbot C;Vogel C;Madera M;Chothia C;Gough J
通讯作者：
Gough J
影响因子：
3
作者：
Cheek S;Qi Y;Krishna SS;Kinch LN;Grishin NV
通讯作者：
Grishin NV
影响因子：
14.9
作者：
Chandonia, JM;Walker, NS;Brenner, SE
通讯作者：
Brenner, SE
影响因子：
5.6
作者：
Gough, J;Karplus, K;Chothia, C
通讯作者：
Chothia, C
影响因子：
14.9
作者：
Andreeva, Antonina;Howorth, Dave;Chandonia, John-Marc;Brenner, Steven E.;Hubbard, Tim J. P.;Chothia, Cyrus;Murzin, Alexey G.
通讯作者：
Murzin, Alexey G.