Obesity, not a high fat, high sucrose diet alone, induced glucose intolerance and cardiac dysfunction during pregnancy and postpartum.
Obesity, not a high fat, high sucrose diet alone, induced glucose intolerance and cardiac dysfunction during pregnancy and postpartum.
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DOI：
10.1038/s41598-021-97336-x
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发表时间：
2021-09-10
影响因子：
4.6
通讯作者：
Umeda M
中科院分区：
文献类型：
--
作者：
Chung E;Gonzalez K;Ullevig SL;Zhang J;Umeda M
心血管疾病是妇女在怀孕期间和产后期间死亡的主要原因。肥胖是心血管疾病的独立危险因素。近60%的育龄妇女被认为超重或肥胖，心血管疾病的发病率和死亡率继续普遍存在。本研究的目的是确定致肥饮食对妊娠期和产后母鼠心脏代谢健康的影响。雌性小鼠在妊娠开始前8周和整个研究期间喂食高脂肪、高蔗糖饮食（HFHS）或精制对照饮食（CON）。HFHS中的小鼠表现出两种不同的表型，肥胖倾向（HFHS/OP）和肥胖抵抗（HFHS/OR）。妊娠前肥胖（HFHS/OP）在妊娠前和产后引起葡萄糖耐受不良。HFHS/OP组的收缩功能（%FS）在妊娠晚期（与HFHS/OR组相比）和断奶（与CON组相比）显著降低，但在产后6周时各组间无差异。在产后期间未发现诱导病理性心脏肥大标志物。血浆脂联素下降，而总胆固醇增加HFHS/OP。我们的研究结果表明，肥胖，而不是单独的饮食，在怀孕期间和产后的心脏适应性产生负面影响。
Cardiovascular disease is the leading cause of death in women during pregnancy and the postpartum period. Obesity is an independent risk factor for cardiovascular diseases. Nearly 60% of women of reproductive age are considered overweight or obese, cardiovascular disease morbidity and mortality continue to be pervasive. The objective of this study was to determine the effects of an obesogenic diet on the cardiometabolic health of dams during pregnancy and postpartum. Female mice were fed either a high-fat, high-sucrose diet (HFHS) or a refined control diet (CON) for 8 weeks before initiation of pregnancy and throughout the study period. Mice in the HFHS showed two distinct phenotypes, obesity-prone (HFHS/OP) and obesity resistance (HFHS/OR). Pre-pregnancy obesity (HFHS/OP) induced glucose intolerance before pregnancy and during postpartum. Systolic function indicated by the percent fractional shortening (%FS) was significantly decreased in the HFHS/OP at late pregnancy (vs. HFHS/OR) and weaning (vs. CON), but no differences were found at 6 weeks of postpartum among groups. No induction of pathological cardiac hypertrophy markers was found during postpartum. Plasma adiponectin was decreased while total cholesterol was increased in the HFHS/OP. Our results suggested that obesity, not the diet alone, negatively affected cardiac adaptation during pregnancy and postpartum.
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