Mouse models for studying genetic influences on factors determining smoking cessation success in humans.
Mouse models for studying genetic influences on factors determining smoking cessation success in humans.
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DOI：
10.1111/j.1749-6632.2011.06415.x
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发表时间：
2012-02
影响因子：
5.2
通讯作者：
Uhl GR
中科院分区：
文献类型：
--
作者：
Hall FS;Markou A;Levin ED;Uhl GR
Humans differ in their ability to quit using addictive substances, including nicotine, the major psychoactive ingredient in tobacco. For tobacco smoking, a substantial body of evidence, largely derived from twin studies, indicates that approximately half of these individual differences in ability to quit are heritable, genetic influences that likely overlap with those for other addictive substances. Both twin and molecular genetic studies support overlapping influences on nicotine addiction vulnerability and smoking cessation success, although there is little formal analysis of the twin data that supports this important point. None of the current datasets provides clear data concerning which heritable factors might provide robust dimensions around which individuals differ in ability to quit smoking. One approach to this problem is to test mice with genetic variations in genes that contain human variants that alter quit-success. This review considers which features of quit success should be included in a comprehensive approach to elucidating the genetics of quit success, and how those features may be modeled in mice.
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DOI：
10.1523/jneurosci.2258-10.2010
发表时间：
2010-07-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bailey CD;De Biasi M;Fletcher PJ;Lambe EK
通讯作者：
Lambe EK
影响因子：
1.6
作者：
Bernal, MC;Vicens, P;Redolat, R
通讯作者：
Redolat, R
影响因子：
3.4
作者：
Balerio, GN;Aso, E;Maldonado, R
通讯作者：
Maldonado, R
影响因子：
4.4
作者：
Beckham, Jean C.;Dennis, Michelle F.;Vrana, Scott R.
通讯作者：
Vrana, Scott R.
影响因子：
4.7
作者：
Andre, Jessica M.;Leach, Prescott T.;Gould, Thomas J.
通讯作者：
Gould, Thomas J.