Reduced retrograde labeling of diencephalic-projecting neurons in the gracile nucleus of the monkey following removal of dorsal column input.
Reduced retrograde labeling of diencephalic-projecting neurons in the gracile nucleus of the monkey following removal of dorsal column input.
复制标题
去除背柱输入后，猴子薄核中间脑投射神经元的逆行标记减少。
DOI：
10.1006/exnr.1993.1140
复制
发表时间：
1993
影响因子：
5.3
通讯作者：
VierckJr,CJ
中科院分区：
文献类型：
--
作者：
Berkley,KJ;VierckJr,CJ
作为神经元对背柱核的传入神经阻滞的解剖学研究的一部分，研究了背柱核中丘脑投射细胞对HRP的摄取和逆行转运。13只猕猴的丘脑腹侧基底部注射HRP的时间范围从3到364天后，打算在中到上胸部水平的一侧薄束横断。薄束完全病变同侧薄束核中标记细胞的密度与不完全病变完全支配或部分去神经支配的对侧薄束核中标记细胞的密度进行比较。此外，在完全神经支配的楔状核的标记细胞的密度进行了比较。一般来说，在同侧薄核中标记细胞的密度减少，以完成病变。该侧楔形核中的标记细胞没有相应的减少。这一结果证实了脊髓运动神经元和丘脑皮质投射细胞在外侧膝状体神经元传入神经阻滞后的影响。然而，试图定义一个时间过程中减少运输的丘系投射细胞揭示了一个效果，这是戏剧性的，在一些动物，部分在其他人，而不是在其余的证明，没有一个明确的关系，手术后的时间。这一结果与一篇文献相关，该文献描述了传入神经阻滞的各种形态学、生化、电生理和行为影响，这些影响似乎在神经元损伤后随着时间的推移而增强和减弱。
As part of an anatomical investigation of neuronal responses to deafferentation of the dorsal column nuclei by transection of the dorsal spinal columns, the uptake and retrograde transport of HRP by thalamic projection cells in the dorsal column nuclei was studied. The ventrobasal thalamus of 13 macaque monkeys was injected bilaterally with HRP at periods ranging from 3 to 364 days following intended unilateral transection of fasciculus gracilis at a mid- to upper thoracic level. The density of labeled cells in the gracile nuclei ipsilateral to complete lesions of fasciculus gracilis was compared with the density of labeled cells in the contralateral gracile nuclei that were fully innervated or partially denervated by an incomplete lesion. Also, the density of labeled cells in the fully innervated cuneate nuclei was compared. In general, there was a reduction in density of labeled cells in the gracile nuclei ipsilateral to complete lesions. without a corresponding decrement in labeled cells in the cuneate nuclei on that side. This result confirms effects on spinal motoneurons and on thalamocortical projection cells in the lateral geniculate nucleus following deafferentation. However, attempts to define a time course for the reduction in transport by lemniscal projection cells revealed an effect that was dramatic in some animals, partial in others, and not demonstrable in the remainder, without a clear relationship to time after surgery. This result is related to a literature which describes a variety of morphological, biochemical, electrophysiological, and behavioral effects of deafferentation which appear to wax and wane with time after neuronal injury.
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DOI：
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发表时间：
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影响因子：
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DOI：
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发表时间：
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期刊：
Experimental and molecular pathology (Print)
影响因子：
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作者：
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影响因子：
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