The Real Need for Regenerative Medicine in the Future of Congenital Heart Disease Treatment.
The Real Need for Regenerative Medicine in the Future of Congenital Heart Disease Treatment.
复制标题
先天性心脏病治疗未来对再生医学的真实的需求。
DOI：
10.3390/biomedicines9050478
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发表时间：
2021-04-27
期刊：
影响因子：
4.7
通讯作者：
Shinoka T
中科院分区：
文献类型：
--
作者：
Matsuzaki Y;Wiet MG;Boe BA;Shinoka T
由高分子化合物制成的生物可吸收材料已被用于再生医学的许多领域，以促进组织再生。这些材料取代自体组织，由于其生长潜力，在治疗先天性心脏病的心血管应用中成为极好的替代品。然而，它们在小儿心血管外科的理论优势与实际临床应用之间仍有较大差距。这篇综述将集中在再生医学的四个领域，其中生物可吸收材料有可能减轻目前治疗方案在儿科心血管手术领域无法减轻的负担。这四个领域包括组织工程肺瓣膜、组织工程贴片、治疗肺静脉狭窄的再生医学选择和组织工程血管移植。我们将讨论迄今为止报道的生物相容性材料的研究和发展，材料在体外的评估，以及已经进展到临床试验的研究结果。
Bioabsorbable materials made from polymeric compounds have been used in many fields of regenerative medicine to promote tissue regeneration. These materials replace autologous tissue and, due to their growth potential, make excellent substitutes for cardiovascular applications in the treatment of congenital heart disease. However, there remains a sizable gap between their theoretical advantages and actual clinical application within pediatric cardiovascular surgery. This review will focus on four areas of regenerative medicine in which bioabsorbable materials have the potential to alleviate the burden where current treatment options have been unable to within the field of pediatric cardiovascular surgery. These four areas include tissue-engineered pulmonary valves, tissue-engineered patches, regenerative medicine options for treatment of pulmonary vein stenosis and tissue-engineered vascular grafts. We will discuss the research and development of biocompatible materials reported to date, the evaluation of materials in vitro, and the results of studies that have progressed to clinical trials.
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影响因子：
--
作者：
Bernabei, Massimo;Margaryan, Rafik;Murzi, Bruno
通讯作者：
Murzi, Bruno
影响因子：
14
作者：
Dijkman, Petra E.;Driessen-Mol, Anita;Baaijens, Frank P. T.
通讯作者：
Baaijens, Frank P. T.
影响因子：
14
作者：
Badylak, Stephen F.
通讯作者：
Badylak, Stephen F.
影响因子：
1.6
作者：
Bezuska, Laurynas;Lebetkevicius, Virgilijus;Tarutis, Virgilijus
通讯作者：
Tarutis, Virgilijus
影响因子：
37.8
作者：
COHEN, M;FUSTER, V;MCGOON, DC
通讯作者：
MCGOON, DC