Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization.
Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization.
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DOI：
10.1016/j.bbr.2012.10.034
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发表时间：
2013-02-01
影响因子：
2.7
通讯作者：
Unterwald, Ellen M.
中科院分区：
文献类型：
--
作者：
Craige, Caryne P.;Unterwald, Ellen M.
Previous studies have identified an inhibitory regulatory role of the 5-HT2C receptor in serotonin and dopamine neurotransmission. As cocaine is known to enhance serotonin and dopamine transmission, the ability of 5-HT2C receptors to modulate cocaine-induced behaviors was investigated. Alterations in cocaine reward behavior were assessed in the conditioned place preference (CPP) paradigm. Mice were injected with a selective 5-HT2C receptor agonist, Ro 60-0175 (0, 1, 3, 10 mg/kg, i.p.) prior to cocaine administration (10 mg/kg, i.p.) on cocaine-conditioning days. Administration of Ro 60-0175 (10 mg/kg) prior to cocaine attenuated the development of cocaine place preference. To assess the potential of the 5-HT2C receptor to influence cocaine-induced behavioral sensitization, mice were pretreated with either saline or Ro 60-0175 (10 mg/kg, i.p.) and 30 minutes later, administered cocaine (20 mg/kg, i.p.) or saline once daily for 5 days. Locomotor activity was measured daily following cocaine administration. After a 10-day drug-free period, locomotor activity was measured on day 16 following a challenge injection of cocaine (20 mg/kg, i.p.). Pharmacological activation of 5-HT2C receptors with Ro 60-0175 attenuated acute cocaine-induced activity on days 1–5, as well as the development of long-term cocaine-induced locomotor sensitization. Thus, activation of 5-HT2C receptors attenuated the rewarding and locomotor-stimulating effects of cocaine, as well as inhibited the development of sensitization. The current study shows that 5-HT2C receptor activity exerts an inhibitory influence on the short-term and long-term behavioral responses to cocaine.
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影响因子：
1.6
作者：
Neisewander, Janet L.;Acosta, Jamin I.
通讯作者：
Acosta, Jamin I.
影响因子：
3.6
作者：
NICOLAYSEN, LC;JUSTICE, JB
通讯作者：
JUSTICE, JB
影响因子：
6.1
作者：
RITZ, MC;CONE, EJ;KUHAR, MJ
通讯作者：
KUHAR, MJ
影响因子：
56.9
作者：
RITZ, MC;LAMB, RJ;KUHAR, MJ
通讯作者：
KUHAR, MJ
影响因子：
5
作者：
Huang, Mei;Dai, Jin;Meltzer, Herbert Y.
通讯作者：
Meltzer, Herbert Y.