Molecular implications of repeated aggression: Th, Dat1, Snca and Bdnf gene expression in the VTA of victorious male mice.
Molecular implications of repeated aggression: Th, Dat1, Snca and Bdnf gene expression in the VTA of victorious male mice.
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DOI：
10.1371/journal.pone.0004190
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Kudryavtseva NN
中科院分区：
文献类型：
--
作者：
Bondar NP;Boyarskikh UA;Kovalenko IL;Filipenko ML;Kudryavtseva NN
人们普遍认为，反复出现的攻击行为可能是各种精神疾病的结果。我们研究的目的是分析中脑腹侧被盖区 (VTA) 中可能与雄性小鼠在特殊实验环境中一贯表现出的攻击性有关的基因的 mRNA 水平。这些基因是Th、Dat1、Snca和Bdnf；雄性小鼠是一组每天连续赢得 20 次战斗的动物，也是一组拥有相同获胜记录并随后 14 天不打架的动物。与对照组相比，刚参加战斗的组的 Th、Dat1 和 Snca mRNA 水平有所增加。与对照组相比，非战斗获胜者的 Th 和 Dat1 mRNA 水平有所增加。攻击性水平与 Th 和 Snca mRNA 水平之间发现显着正相关。反复的正面战斗经历会增强 Th、Dat1 和 Snca 基因的表达，这些基因与大脑多巴胺能系统相关。 Th和Dat1基因的表达长期保持增强。
It is generally recognized that recurrent aggression can be the result of various psychiatric disorders. The aim of our study was to analyze the mRNA levels, in the ventral tegmental area (VTA) of the midbrain, of the genes that may possibly be associated with aggression consistently shown by male mice in special experimental settings. The genes were Th, Dat1, Snca and Bdnf; the male mice were a group of animals that had each won 20 daily encounters in succession and a group of animals that had the same winning track record followed by a no-fight period for 14 days. Increased Th, Dat1 and Snca mRNA levels were in the fresh-from-the-fight group as compared to the controls. Increased Th and Dat1 mRNA levels were in the no-fight winners as compared to the controls. Significant positive correlations were found between the level of aggression and Th and Snca mRNA levels. Repeated positive fighting experience enhances the expression of the Th, Dat1 and Snca genes, which are associated with brain dopaminergic systems. The expression of the Th and Dat1 genes stays enhanced for a long time.
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