Targeted peptide-modified oxidized mesoporous carbon nanospheres for chemo-thermo combined therapy of ovarian cancer in vitro.
Targeted peptide-modified oxidized mesoporous carbon nanospheres for chemo-thermo combined therapy of ovarian cancer in vitro.
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DOI：
10.1080/10717544.2022.2089298
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发表时间：
2022-12
期刊：
影响因子：
6
通讯作者：
中科院分区：
文献类型：
--
作者：
由于现有治疗方案的许多缺点，卵巢癌仍然是严重危害人类健康的疾病之一。本研究成功地制备了以I6P8多肽为靶向白介素6受体(IL-6RS)、氧化介孔碳纳米球(OMCN)为近红外(NIR)触发药物载体、阿霉素(DOX)为化疗药物和荧光剂的多功能化热联合治疗纳米平台(OMCNPID)。所合成的多功能纳米平台具有较高的药物存储容量和优异的光热性能。此外，在低pH和近红外激光照射的条件下，由于DOX从OMCN的石墨核上解离，DOX从OMCNPID中迅速释放。体外实验结果表明，OMCNPID能被SKOV-3单层细胞和肿瘤球体明显摄取，对卵巢癌具有显著的协同化疗-光热效应。这些结果表明，OMCNPID是一种pH/NIR双刺激响应型纳米平台，可以实现高效的化热联合治疗。
Ovarian cancer remains one of serious hazards to human health due to many drawbacks of existing available treatment options. In this study, a multifunctional chemo-thermo combined therapy nanoplatform (OMCNPID) was successfully prepared, which is composed of I6P8 peptide as a targeting moiety to interleukin-6 receptors (IL-6Rs), oxidized mesoporous carbon nanospheres (OMCN) as a near infrared (NIR)-triggered drug carrier and doxorubicin (DOX) as a chemotherapeutic drug and fluorescent agent. The synthesized multifunctional nanoplatform displayed high storage capacity for drugs and excellent photothermal properties. Besides, DOX was rapidly released from OMCNPID at the condition of low pH and NIR laser irradiation due to the dissociation of DOX from graphitic cores of OMCN. In vitro experimental results verified that OMCNPID could be markedly taken up by SKOV-3 monolayer cells and tumor spheroids, and revealed a remarkable synergistic chemo-photothermal effect against ovarian cancer. All the results demonstrated that OMCNPID is a pH/NIR dual-stimulus responsive nanoplatform and can achieve efficient chemo-thermo combined therapy.
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DOI：
10.1016/j.colsurfa.2021.127791
发表时间：
2021-11-17
影响因子：
5.2
作者：
Atila Dincer, Ceren;Getiren, Bengu;Yildiz, Nuray
通讯作者：
Yildiz, Nuray
影响因子：
5.1
作者：
Galhano, Joana;Marcelo, Goncalo A.;Oliveira, Elisabete
通讯作者：
Oliveira, Elisabete
影响因子：
3.1
作者：
Levin, Tzuriel;Sade, Hagit;Lellouche, Jean-Paul
通讯作者：
Lellouche, Jean-Paul
影响因子：
6.1
作者：
Wang, Xudong;Dai, Jun;Xia, Fan
通讯作者：
Xia, Fan
多功能肿瘤靶向 PLGA 纳米颗粒可传递 Pt(IV)/siBIRC5，用于 US/MRI 成像并克服卵巢癌耐药性。
影响因子：
14
作者：
Zhang, Yanhua;Dong, Yang;Sun, Ying
通讯作者：
Sun, Ying