Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis.
Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis.
复制标题
DOI：
10.3390/ijms17060868
复制
发表时间：
2016-06-02
影响因子：
5.6
通讯作者：
Ohtsuki M
中科院分区：
文献类型：
--
作者：
Pittayapruek P;Meephansan J;Prapapan O;Komine M;Ohtsuki M
基质金属蛋白酶(MMPs)是一种含锌的内肽酶，具有广泛的底物特异性。总的来说，这些酶能够降解细胞外基质(ECM)蛋白的各种成分。根据它们的结构和底物特异性，它们可以分为五个主要亚类，即(1)胶原酶(MMP-1、MMP-8和MMP-13)；(2)明胶酶(MMP-2和MMP-9)；(3)基质蛋白(MMP-3、基质金属蛋白酶10和基质金属蛋白酶11)；(4)基质基质蛋白(基质金属蛋白酶-7和基质金属蛋白酶26)；(5)膜型基质金属蛋白酶(MT)(基质金属蛋白酶-14、基质金属蛋白酶15和基质金属蛋白酶16)。基质金属蛋白酶对细胞外基质的改变可能会导致皮肤皱纹，这是皮肤过早老化的特征。在光致癌过程中，ECM的降解是肿瘤细胞侵袭的第一步，侵袭基底膜和周围间质，主要由纤维状胶原蛋白组成。此外，MMPs还参与促进癌细胞生长和迁移的血管生成。本文就皮肤过早老化和皮肤癌，如基底细胞癌、鳞状细胞癌和黑色素瘤等的研究现状作一综述，重点介绍基质金属蛋白酶家族的成员及其功能。
Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases with an extensive range of substrate specificities. Collectively, these enzymes are able to degrade various components of extracellular matrix (ECM) proteins. Based on their structure and substrate specificity, they can be categorized into five main subgroups, namely (1) collagenases (MMP-1, MMP-8 and MMP-13); (2) gelatinases (MMP-2 and MMP-9); (3) stromelysins (MMP-3, MMP-10 and MMP-11); (4) matrilysins (MMP-7 and MMP-26); and (5) membrane-type (MT) MMPs (MMP-14, MMP-15, and MMP-16). The alterations made to the ECM by MMPs might contribute in skin wrinkling, a characteristic of premature skin aging. In photocarcinogenesis, degradation of ECM is the initial step towards tumor cell invasion, to invade both the basement membrane and the surrounding stroma that mainly comprises fibrillar collagens. Additionally, MMPs are involved in angiogenesis, which promotes cancer cell growth and migration. In this review, we focus on the present knowledge about premature skin aging and skin cancers such as basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and melanoma, with our main focus on members of the MMP family and their functions.
DOI：
10.1080/13102818.2014.947694
发表时间：
2014-09-03
期刊：
Biotechnology, biotechnological equipment
影响因子：
--
作者：
Vlaykova T;Kurzawski M;Tacheva T;Dimov D;Gulubova M;Yovchev Y;Chakarov S;Drozdzik M
通讯作者：
Drozdzik M