Investigation of the role of MMP3 -1171insA polymorphism in cutaneous malignant melanoma - a preliminary study.
Investigation of the role of MMP3 -1171insA polymorphism in cutaneous malignant melanoma - a preliminary study.
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DOI：
10.1080/13102818.2014.947694
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发表时间：
2014-09-03
期刊：
影响因子：
--
通讯作者：
Drozdzik M
中科院分区：
文献类型：
--
作者：
Vlaykova T;Kurzawski M;Tacheva T;Dimov D;Gulubova M;Yovchev Y;Chakarov S;Drozdzik M
同时期恶性黑色素瘤是世界范围内最具侵袭性的皮肤癌，死亡率高。基底膜和细胞外基质的降解是肿瘤侵袭和转移的重要环节。基质金属蛋白酶（MMPs）及其组织抑制剂（TIMPs）在这一过程中起关键作用。MMP-3也被称为基质溶解素-1，是发现与癌症相关的第一种蛋白酶。在MMP-3（MMP 3）基因中，启动子区-1171位A核苷酸的插入/缺失已被鉴定并显示影响该基因的表达活性。本研究在保加利亚患者（n = 26）和未受影响的对照组（n = 172）中进行了一项试点病例对照研究，以调查MMP 3 - 1171 insA多态性与皮肤恶性黑色素瘤风险的关系。对照组和黑色素瘤患者的基因型均符合Hardy-Weinberg平衡。结果显示，无论是在粗分析中（p = 0.360和0.790，c2检验）还是在校正年龄和性别后，黑素瘤患者和健康对照者之间MMP 3 - 1171 insA多态性的基因型和等位基因频率均无统计学显著差异。不同基因型患者的一些临床特征的比较显示，与5A等位基因携带者相比，6A/6A基因型患者的生存期更长（5A/5A+5A/6A基因型，p = 0.118，Log rank检验）。我们目前的初步研究结果没有提供证据证明MMP 3启动子多态性-1171insA作为共时性黑色素瘤发展的危险因素，但表明其在疾病进展中的意义。
Coetaneous malignant melanoma is the most aggressive cancer of the skin with a high rate of mortality worldwide. Degradation of basement membranes and extracellular matrix is an essential step in cancer invasion and metastasis. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play key roles in this step. MMP-3 also called stromelysin-1 was one of the first proteinases found to be associated with cancer. In the gene of MMP-3 (MMP3), an insertion/deletion of an A nucleotide at position -1171 in promoter region has been identified and shown to effect the expression activity of the gene. The present study was conducted to investigate the relation of MMP3 -1171insA polymorphism with skin malignant melanoma risk in a pilot case-control study of Bulgarian patients (n = 26) and unaffected controls (n = 172). The genotypes of controls and melanoma patients were in Hardy-Weinberg equilibrium. The results showed no statistically significant difference both in genotype and allele frequencies of MMP3 -1171insA polymorphism between melanoma patients and healthy controls either in crude analyses (p = 0.360 and 0.790, c2-test) or after adjustment for age and sex. The comparison of some clinical characteristics between the patients with different genotypes showed a trend for longer survival of patients with 6A/6A genotype compared to the carriers of 5A allele (5A/5A+5A/6A genotypes, p = 0.118, Log rank test). The results of our current preliminary study do not provide evidence for the role of the promoter polymorphism -1171insA in MMP3 as a risk factor for development of coetaneous melanoma, but suggest its implication in progression of the diseases.
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影响因子：
3.5
作者：
Hu, Chaoliang;Wang, Jianmiao;Zhao, Jianping
通讯作者：
Zhao, Jianping
影响因子：
3.7
作者：
Zhang C;Li C;Zhu M;Zhang Q;Xie Z;Niu G;Song X;Jin L;Li G;Zheng H
通讯作者：
Zheng H
影响因子：
4.8
作者：
Ye, S;Eriksson, P;Henney, AM
通讯作者：
Henney, AM
DOI：
10.1007/s004280050443
发表时间：
1999-12-01
期刊：
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
影响因子：
--
作者：
Walker, RA;Woolley, DE
通讯作者：
Woolley, DE
影响因子：
1.2
作者：
Okamoto, Kinya;Ishida, Chihiro;Yuasa, Isao
通讯作者：
Yuasa, Isao