Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab.
Retinal Surface Macrophage Changes in Thyroid Eye Disease before and after Treatment with Teprotumumab.
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DOI：
10.1155/2022/5275309
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Reddy HS
中科院分区：
文献类型：
--
作者：
Otero-Marquez O;Fayad M;Pinhas A;Chui TYP;Rosen RB;Reddy HS
视网膜表面巨噬细胞在调节免疫反应、维持玻璃体透明性和组织修复中起关键作用。我们检查了甲状腺眼病（TED）患者在使用teprotumumab（Tepezza，Horizon therapeutics）治疗前后角膜旁表面巨噬细胞的变化。使用临床正面OCT对治疗前和治疗后的骨旁表面巨噬细胞进行成像，并使用新型细胞密度图技术评估其密度。处理前，表面巨噬细胞密度高。巨噬细胞具有不均匀的空间分布，并且它们的外观是圆形的，几乎没有突起，与“活化”状态一致。处理后，细胞密度下降。巨噬细胞间隔规则，具有分枝状外观和丝状伪足样突起，与“静止”状态一致。表面巨噬细胞密度随着teprotumumab治疗的临床活动评分（CAS）降低而降低，表明这些细胞与之前未在TED中描述的潜在眼内和视网膜炎症过程可能相关。
Retinal surface macrophages play key roles in the regulation of immune response, maintenance of vitreous clarity, and tissue repair. We examined the variation of parafoveal surface macrophages in a thyroid eye disease (TED) patient before and after treatment with teprotumumab (Tepezza, Horizon therapeutics). Pre- and posttreatment parafoveal surface macrophages were imaged using clinical en face OCT, and their density was assessed using a novel cell density mapping technique. Pretreatment, surface macrophage cell density was high. Macrophages had a nonuniform spatial distribution, and their appearance was round with few protrusions, consistent with an “activated” state. Posttreatment, cell density decreased. The macrophages were regularly spaced and had a ramified appearance and filopodia-like processes, consistent with a “quiescent” state. Surface macrophage density decreased as the Clinical Activity Score (CAS) decreased with teprotumumab treatment, suggesting a potential association of these cells with an underlying intraocular and retinal inflammatory process previously not described in TED.
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