Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study.
Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study.
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DOI：
10.4196/kjpp.2017.21.6.651
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Han J
中科院分区：
文献类型：
--
作者：
Bang HS;Seo DY;Chung YM;Kim DH;Lee SJ;Lee SR;Kwak HB;Kim TN;Kim M;Oh KM;Son YJ;Kim S;Han J
补充熊果酸(UA)之前被证明可以改善接受阻力训练的男性的骨骼肌功能。本研究旨在采用相同的实验范式，确定尿酸对耐力训练男性运动性骨骼肌损伤标志物是否也有有益影响，包括皮质醇、B型利钠肽(BNP)、肌红蛋白、肌酸激酶(CK)、肌酸激酶-心肌带(CK-MB)和乳酸脱氢酶(LDH)的水平。16名健康受试者随机分为耐力训练组(RT)和RT+UA组(n=8)。受试者按RT程序进行训练(60%~80%重复1次，每周6次)，UA组在此基础上补充UA(450 mg/d)，共8周。干预前后采集血样，分析皮质醇、脑钠素、肌红蛋白、肌酸激酶、肌酸激酶同工酶和乳酸脱氢酶水平。单纯接受RT的受试者在体成分和骨骼肌损伤指标方面没有明显变化，而RT+UA组的体重和体脂百分比略有下降，瘦体重略有增加，但无统计学意义。此外，补充尿酸显著降低了BNP、CK、CK-MB和LDH水平(p<；0.05)。综上所述，补充尿酸可减轻放疗后骨骼肌损伤标志物的增加。这一发现为受过抵抗训练的男性提供了一种潜在的新疗法的证据。
Ursolic acid (UA) supplementation was previously shown to improve skeletal muscle function in resistance-trained men. This study aimed to determine, using the same experimental paradigm, whether UA also has beneficial effects on exercise-induced skeletal muscle damage markers including the levels of cortisol, B-type natriuretic peptide (BNP), myoglobin, creatine kinase (CK), creatine kinase-myocardial band (CK-MB), and lactate dehydrogenase (LDH) in resistance-trained men. Sixteen healthy participants were randomly assigned to resistance training (RT) or RT+UA groups (n=8 per group). Participants were trained according to the RT program (60~80% of 1 repetition, 6 times/week), and the UA group was additionally given UA supplementation (450 mg/day) for 8 weeks. Blood samples were obtained before and after intervention, and cortisol, BNP, myoglobin, CK, CK-MB, and LDH levels were analyzed. Subjects who underwent RT alone showed no significant change in body composition and markers of skeletal muscle damage, whereas RT+UA group showed slightly decreased body weight and body fat percentage and slightly increased lean body mass, but without statistical significance. In addition, UA supplementation significantly decreased the BNP, CK, CK-MB, and LDH levels (p<0.05). In conclusion, UA supplementation alleviates increased skeletal muscle damage markers after RT. This finding provides evidence for a potential new therapy for resistance-trained men.
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影响因子：
29
作者：
Kunkel SD;Suneja M;Ebert SM;Bongers KS;Fox DK;Malmberg SE;Alipour F;Shields RK;Adams CM
通讯作者：
Adams CM
DOI：
10.1152/ajpregu.2001.280.5.r1292
发表时间：
2001-05-01
影响因子：
2.8
作者：
Koskinen, SOA;Wang, W;Takala, TES
通讯作者：
Takala, TES
影响因子：
1.9
作者：
Mendes, Romeu;Sousa, Nelson;Reis, Victor
通讯作者：
Reis, Victor
影响因子：
4.3
作者：
Ma, Jie-Qiong;Ding, Jie;Liu, Chan-Min
通讯作者：
Liu, Chan-Min
DOI：
10.1007/bf00635996
发表时间：
1988-02-01
期刊：
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY
影响因子：
--
作者：
FRIDEN, J;SEGER, J;EKBLOM, B
通讯作者：
EKBLOM, B