Spatial and temporal distribution of visual information coding in lateral prefrontal cortex.

Spatial and temporal distribution of visual information coding in lateral prefrontal cortex.
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DOI:
10.1111/ejn.12754
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发表时间:
2015-01
期刊:
The European journal of neuroscience
影响因子:
--
通讯作者:
Duncan J
Duncan J
中科院分区:
其他
文献类型:
--
作者:
Kadohisa M;Kusunoki M;Petrov P;Sigala N;Buckley MJ;Gaffan D;Duncan J

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前额叶神经元编码许多与行为相关的视觉信息。在行为猴子,我们使用了一个线索目标检测任务,以解决编码的对象,行为类别和空间位置,检查神经活动的时间演变的背侧和腹侧区域的外侧前额叶皮层(包括部分区域9,46,45 A和8A),并在两个大脑半球。在每个半球内,几乎没有区域专门化的证据,背侧和腹侧区域的神经元对物体、类别和位置的选择性表现出非常相似的模式。然而,对于任何一个视野中的刺激,两个大脑半球的反应都存在强烈的时间特异性差异。在视觉反应的第一部分(从刺激开始的50-250毫秒),在每个半球的处理主要限于对侧刺激,强烈的反应,这样的刺激,和选择性的对象和类别。之后(300-500 ms),对同侧刺激的反应也出现了,许多细胞现在对同侧刺激的反应比对侧刺激更强烈,并且许多细胞表现出对类别的选择性。对错误的活动试验表明,在两个半球的后期活动反映了动物的最终决定。当信息被加工成一个行为决策时,它的编码扩展到包括大的双侧前额叶皮层区域。
Prefrontal neurons code many kinds of behaviourally relevant visual information. In behaving monkeys, we used a cued target detection task to address coding of objects, behavioural categories and spatial locations, examining the temporal evolution of neural activity across dorsal and ventral regions of the lateral prefrontal cortex (encompassing parts of areas 9, 46, 45A and 8A), and across the two cerebral hemispheres. Within each hemisphere there was little evidence for regional specialisation, with neurons in dorsal and ventral regions showing closely similar patterns of selectivity for objects, categories and locations. For a stimulus in either visual field, however, there was a strong and temporally specific difference in response in the two cerebral hemispheres. In the first part of the visual response (50–250 ms from stimulus onset), processing in each hemisphere was largely restricted to contralateral stimuli, with strong responses to such stimuli, and selectivity for both object and category. Later (300–500 ms), responses to ipsilateral stimuli also appeared, many cells now responding more strongly to ipsilateral than to contralateral stimuli, and many showing selectivity for category. Activity on error trials showed that late activity in both hemispheres reflected the animal's final decision. As information is processed towards a behavioural decision, its encoding spreads to encompass large, bilateral regions of prefrontal cortex.
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