Dynamic DNA Methylation in Plant Growth and Development.
Dynamic DNA Methylation in Plant Growth and Development.
复制标题
DOI：
10.3390/ijms19072144
复制
发表时间：
2018-07-23
影响因子：
5.6
通讯作者：
Xiao W
中科院分区：
文献类型：
--
作者：
Bartels A;Han Q;Nair P;Stacey L;Gaynier H;Mosley M;Huang QQ;Pearson JK;Hsieh TF;An YC;Xiao W
DNA甲基化是转座因子沉默、基因组稳定性和基因组印记所需的表观遗传修饰。虽然DNA甲基化已经被深入研究，但不同物种之间甲基化的动态本质才刚刚开始被理解。本文综述了DNA甲基化在不同植物、器官、组织和细胞中的广泛变异，以及在植物生长发育过程中的动态变化和对环境胁迫的响应。总体DNA甲基化在物种之间是相当多样的，并且它发生在被子植物中基因和TE的CG、CHG和CHH（H = A、C或T）背景中。中度表达的基因最有可能在基因体中被甲基化。甲基化水平在转录起始位点上游和转录终止位点附近显著降低;其在启动子中的水平与植物中某些基因的表达呈负相关。甲基化可以通过不同的环境刺激如病原体和非生物胁迫而改变。在真菌、植物和动物在进化过程中分化之前，甲基化可能就存在于共同的真核祖先中。总之，DNA甲基化模式在被子植物中是复杂的，动态的，并且是经过数百万年进化的基因组多样性的组成部分。
DNA methylation is an epigenetic modification required for transposable element (TE) silencing, genome stability, and genomic imprinting. Although DNA methylation has been intensively studied, the dynamic nature of methylation among different species has just begun to be understood. Here we summarize the recent progress in research on the wide variation of DNA methylation in different plants, organs, tissues, and cells; dynamic changes of methylation are also reported during plant growth and development as well as changes in response to environmental stresses. Overall DNA methylation is quite diverse among species, and it occurs in CG, CHG, and CHH (H = A, C, or T) contexts of genes and TEs in angiosperms. Moderately expressed genes are most likely methylated in gene bodies. Methylation levels decrease significantly just upstream of the transcription start site and around transcription termination sites; its levels in the promoter are inversely correlated with the expression of some genes in plants. Methylation can be altered by different environmental stimuli such as pathogens and abiotic stresses. It is likely that methylation existed in the common eukaryotic ancestor before fungi, plants and animals diverged during evolution. In summary, DNA methylation patterns in angiosperms are complex, dynamic, and an integral part of genome diversity after millions of years of evolution.
登录
查看更多内容
影响因子：
10.5
作者：
Bartee, L;Malagnac, F;Bender, J
通讯作者：
Bender, J
影响因子：
64.5
作者：
Calarco JP;Borges F;Donoghue MT;Van Ex F;Jullien PE;Lopes T;Gardner R;Berger F;Feijó JA;Becker JD;Martienssen RA
通讯作者：
Martienssen RA
影响因子：
7
作者：
Gent JI;Ellis NA;Guo L;Harkess AE;Yao Y;Zhang X;Dawe RK
通讯作者：
Dawe RK
DOI：
10.1073/pnas.1209329109
发表时间：
2012-08-07
影响因子：
11.1
作者：
Dowen, Robert H.;Pelizzola, Mattia;Ecker, Joseph R.
通讯作者：
Ecker, Joseph R.
影响因子：
4.6
作者：
An YC;Goettel W;Han Q;Bartels A;Liu Z;Xiao W
通讯作者：
Xiao W