Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling.

Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling.
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DOI:
10.1038/nrn2093
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发表时间:
2007-03
影响因子:
34.7
通讯作者:
Burgoyne, Robert D.
Burgoyne, Robert D.
中科院分区:
医学1区
文献类型:
--
作者:
Burgoyne, Robert D.

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在神经元中,细胞内钙信号在激活神经递质释放和触发神经元功能改变中具有关键作用。钙调素作为一种钙离子传感器已被广泛研究,它在神经元钙离子信号传导中具有几种确定的作用,但神经元钙离子传感器蛋白家族的成员已开始成为许多调节途径中的关键组分,并增加了神经元钙离子信号传导途径的多样性。这些蛋白质的不同性质使它们具有离散的、非冗余的功能。
In neurons, intracellular calcium signals have crucial roles in activating neurotransmitter release and in triggering alterations in neuronal function. Calmodulin has been widely studied as a Ca2+ sensor that has several defined roles in neuronal Ca2+ signalling, but members of the neuronal calcium sensor protein family have begun to emerge as key components in a number of regulatory pathways and have increased the diversity of neuronal Ca2+ signalling pathways. The differing properties of these proteins allow them to have discrete, non-redundant functions.
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