Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally.
Birth weight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally.
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DOI：
10.1371/journal.pone.0047776
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Plagemann A
中科院分区：
文献类型：
--
作者：
Schellong K;Schulz S;Harder T;Plagemann A
超重是主要的挑战性健康风险因素之一。有人声称，出生体重是产前发育状况的关键指标，与长期超重风险有关。为了验证发展和预防医学的这一重要假设，我们进行了系统回顾和综合荟萃分析。通过使用MEDLINE和EMBASE进行文献检索，确定了截至2011年1月发表的研究出生体重与日后超重风险之间关系的相关研究。对于荟萃分析，来自26个国家和五大洲的66项研究被确定为合格，包括643，902名1至75岁的患者。我们构建随机效应和固定效应模型，进行亚组分析，影响分析，评估异质性和发表偏倚，进行荟萃回归分析以及混杂因素调整后的数据分析。荟萃回归分析显示，出生体重与日后超重风险之间存在线性正相关关系（p<0.001）。低出生体重（<2，500 g）被发现伴随着超重风险的降低（比值比（OR）= 0.67; 95%置信区间（CI）0.59-0.76）。 高出生体重（> 4，000 g）与超重风险增加相关（OR = 1.66; 95%CI 1.55-1.77）。 使用正常出生体重（2，500 - 4，000 g）作为参考类别，结果无显著变化（OR = 0.73，95%CI 0.63-0.84和OR = 1.60，95%CI 1.45-1.77）。 亚组和影响分析未显示偏倚/混杂。调整后的估计值表明，与正常出生体重受试者相比，高出生体重受试者的长期超重风险增加一倍（OR = 1.96，95%CI 1.43-2.67）。 研究结果表明，低出生体重会降低超重的长期风险，而高出生体重会导致后来的超重。预防子宫内营养过剩，例如，因此，通过避免孕妇在怀孕期间营养过剩、超重和/或糖尿病，可能是全球真正预防超重的一个有希望的战略。
Overweight is among the major challenging health risk factors. It has been claimed that birth weight, being a critical indicator of prenatal developmental conditions, is related to long-term overweight risk. In order to check this important assumption of developmental and preventive medicine, we performed a systematic review and comprehensive meta-analysis. Relevant studies published up to January 2011 that investigated the relation between birth weight and later risk of overweight were identified through literature searches using MEDLINE and EMBASE. For meta-analysis, 66 studies from 26 countries and five continents were identified to be eligible, including 643,902 persons aged 1 to 75 years. We constructed random-effects and fixed-effects models, performed subgroup-analyses, influence-analyses, assessed heterogeneity and publication bias, performed meta-regression analysis as well as analysis of confounder adjusted data. Meta-regression revealed a linear positive relationship between birth weight and later overweight risk (p<0.001). Low birth weight (<2,500 g) was found to be followed by a decreased risk of overweight (odds ratio (OR) = 0.67; 95% confidence interval (CI) 0.59–0.76). High birth weight (>4,000 g) was associated with increased risk of overweight (OR = 1.66; 95% CI 1.55–1.77). Results did not change significantly by using normal birth weight (2,500–4,000 g) as reference category (OR = 0.73, 95% CI 0.63–0.84, and OR = 1.60, 95% CI 1.45–1.77, respectively). Subgroup- and influence-analyses revealed no indication for bias/confounding. Adjusted estimates indicate a doubling of long-term overweight risk in high as compared to normal birth weight subjects (OR = 1.96, 95% CI 1.43–2.67). Findings demonstrate that low birth weight is followed by a decreased long-term risk of overweight, while high birth weight predisposes for later overweight. Preventing in-utero overnutrition, e.g., by avoiding maternal overnutrition, overweight and/or diabetes during pregnancy, might therefore be a promising strategy of genuine overweight prevention, globally.
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影响因子：
9.8
作者：
Catalano PM;Hauguel-De Mouzon S
通讯作者：
Hauguel-De Mouzon S
影响因子：
8
作者：
Boney, CM;Verma, A;Vohr, BR
通讯作者：
Vohr, BR
影响因子：
4.5
作者：
Apfelbacher, Christian J.;Loerbroks, Adrian;Kraemer, Ursula
通讯作者：
Kraemer, Ursula
DOI：
10.1056/nejmoa1104119
发表时间：
2011-09-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Boggs DA;Rosenberg L;Cozier YC;Wise LA;Coogan PF;Ruiz-Narvaez EA;Palmer JR
通讯作者：
Palmer JR
影响因子：
7.7
作者：
Chen, AM;Pennell, ML;Longnecker, MP
通讯作者：
Longnecker, MP