Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model.
Nasal irrigation efficiently attenuates SARS-CoV-2 Omicron infection, transmission and lung injury in the Syrian hamster model.
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DOI：
10.1016/j.isci.2022.105475
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发表时间：
2022-12-22
期刊：
影响因子：
5.8
通讯作者：
Xia, Ningshao
中科院分区：
文献类型：
--
作者：
Yuan, Lunzhi;Zhu, Huachen;Zhou, Ming;Ma, Jian;Liu, Xuan;Wu, Kun;Ye, Jianghui;Yu, Huan;Chen, Peiwen;Chen, Rirong;Wang, Jia;Zhang, Yali;Ge, Shengxiang;Yuan, Quan;Cheng, Tong;Guan, Yi;Xia, Ningshao
最近，SARS-CoV-2的一个新的变异谱系，即Omicron，成为全球流行的主要毒株。Omicron的多重抗原突变在很大程度上降低了当前疫苗和中和抗体的效率，这突出表明需要更有效和更容易获得的医疗对策。在这里，我们假设通过鼻腔冲洗直接清除病毒可能是一种方便和替代的选择，并在叙利亚仓鼠模型中进行了概念验证实验。有趣的是，与原型相比，Omicron在鼻腔冲洗样品中的病毒RNA、病毒滴度和促炎细胞因子的变化中表现出不同的动态。同时，鼻腔冲洗样品中的病毒载量和促炎细胞因子水平可以指示肺损伤的严重程度。值得注意的是，每日鼻腔冲洗通过降低呼吸道器官中的病毒载量，有效地减轻了感染欧米克隆的仓鼠的炎症和肺损伤。此外，每日鼻腔冲洗可有效抑制病毒通过密切接触传播。每日鼻冲洗抑制SARS-CoV-2复制和密切接触传播每日鼻冲洗可显著降低SARS-CoV-2引起的细胞因子风暴和弥漫性肺损伤鼻冲洗样本中的病毒载量和细胞因子提示肺损伤严重程度；病毒学;免疫反应
Recently, a new variant lineage of SARS-CoV-2, namely Omicron, became the dominant global circulating strain. The multiple antigenic mutations of Omicron largely decrease the efficiency of current vaccines and neutralizing antibodies, which highlights the need for more potent and reachable medical countermeasures. Here, we hypothesize that direct viral clearance by nasal irrigation might be a convenient and alternative option, and perform proof-of-concept experiments in the Syrian hamster model. Interestingly, Omicron shows a different dynamic in the changes of viral RNA, viral titers, and proinflammatory cytokines in nasal rinsing samples when compared with the prototype. Meanwhile, the levels of viral load and proinflammatory cytokines in nasal rinsing samples can indicate the severity of lung injury. Of note, daily nasal irrigation efficiently attenuates inflammation and lung injury in Omicron-infected hamsters by decreasing the viral loads in the respiratory tract organs. Moreover, daily nasal irrigation effectively suppresses viral transmission by close contact. Daily nasal irrigation suppresses SARS-CoV-2 replication and close contact transmission Daily nasal irrigation significantly decreases cytokine storm and diffuse lung injury caused by SARS-CoV-2 Viral load and cytokines in nasal rinsing samples indicate the severity of lung injury Immunology; Virology; Immune response
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影响因子：
64.5
作者：
Hoffmann M;Krüger N;Schulz S;Cossmann A;Rocha C;Kempf A;Nehlmeier I;Graichen L;Moldenhauer AS;Winkler MS;Lier M;Dopfer-Jablonka A;Jäck HM;Behrens GMN;Pöhlmann S
通讯作者：
Pöhlmann S
SARS-CoV-2 Omicron 变种：特征和预防
影响因子：
9.9
作者：
He X;Hong W;Pan X;Lu G;Wei X
通讯作者：
Wei X
影响因子：
39.3
作者：
Balint, Gabor;Voros-Horvath, Barbara;Szechenyi, Aleksandar
通讯作者：
Szechenyi, Aleksandar
DOI：
10.1016/s0140-6736(22)00056-3
发表时间：
2022-01-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Nealon J;Cowling BJ
通讯作者：
Cowling BJ
影响因子：
1.1
作者：
Kosugi EM;Villa JF;Ramos HF;Luz-Matsumoto GR;Serrano TLI;Campos CAC;Barreto CC;Lima CM;Fornazieri MA;Piltcher O;Lessa MM;Romano FR
通讯作者：
Romano FR