Two Main Cellular Components in Rheumatoid Arthritis: Communication Between T Cells and Fibroblast-Like Synoviocytes in the Joint Synovium.
Two Main Cellular Components in Rheumatoid Arthritis: Communication Between T Cells and Fibroblast-Like Synoviocytes in the Joint Synovium.
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类风湿关节炎的两个主要细胞成分：关节滑膜中 T 细胞和成纤维细胞样滑膜细胞之间的通讯
DOI：
10.3389/fimmu.2022.922111
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
风湿性关节炎（RA）是一种慢性自身免疫性疾病，危害全球约1%的人口的健康。目前市场上的RA药物主要包括非甾体抗炎药、生物制剂和疾病修饰药物。这些药物的目的是抑制过度激活的免疫反应或炎症的RA，但他们不能治愈RA。对RA发病机制的深入了解将为寻找RA靶点和药物开发提供新的认识。RA患者滑膜中T细胞浸润和成纤维细胞样滑膜细胞（FLS）过度增殖显著上调。此外，这两种类型的细胞的异常激活已被许多研究证实促进了A过程的发展。本文就RA滑膜组织中T细胞与FLS的相互作用，包括两者之间的单向/相互调节和直接/间接调节进行了系统的综述。本研究旨在从T细胞与FLS相互调节的角度探讨RA的发病机制，为RA的研究提供新的思路。
Rheumatoid arthritis (RA) is a chronic autoimmune disease that endangers the health of approximately 1% of the global population. Current RA medications on the market mainly include non-steroidal anti-inflammatory drugs, biological agents, and disease-modifying drugs. These drugs aim to inhibit the overactivated immune response or inflammation of RA, but they cannot cure RA. A better understanding of the pathogenesis of RA will provide a new understanding to search for RA targets and for drug development. The infiltration of T cells and hyper-proliferation of fibroblast-like synoviocytes (FLS) in the synovium of patients with RA are significantly upregulated. Furthermore, the abnormal activation of these two types of cells has been confirmed to promote development of the course of A by many studies. This article systematically summarizes the interactions between T cells and FLS in RA synovial tissues, including one-way/mutual regulation and direct/indirect regulation between the two. It further aims to investigate the pathogenesis of RA from the perspective of mutual regulation between T cells and FLS and to provide new insights into RA research.
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影响因子：
7.8
作者：
Kang，Shin Eui;Park，Jin Kyun;Song，Yeong Wook
通讯作者：
Song，Yeong Wook
影响因子：
4.9
作者：
Bustamante MF;Garcia-Carbonell R;Whisenant KD;Guma M
通讯作者：
Guma M
DOI：
10.1155/2020/1706837
发表时间：
2020-05-20
影响因子：
--
作者：
Chen, Hening;Wang, Changzhi;Chai, Lenin
通讯作者：
Chai, Lenin
影响因子：
--
作者：
Eljaafari, Assia;Tartelin, Marie-Laure;Miossec, Pierre
通讯作者：
Miossec, Pierre
影响因子：
2.2
作者：
Kato, Hiroshi;Endres, Judith;Fox, David A.
通讯作者：
Fox, David A.