Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China.
Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China.
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中国维吾尔族女性PGF和TNFAIP2基因多态性与宫颈癌风险相关
DOI：
10.1186/s12881-020-01144-5
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发表时间：
2020-10-27
影响因子：
--
通讯作者：
Niyazi M
中科院分区：
文献类型：
--
作者：
Ainiwaer Z;Maisaidi R;Liu J;Han L;Husaiyin S;Lu J;Niyazi M
背景：PGF和TNFAIP 2是重要的血管生成因子，在宫颈癌中异常表达。然而，目前还没有报告调查的关系ofPGF和TNFAIP 2基因多态性CC risk.MethodsWe进行了病例对照研究，342例CC患者和498例无癌对照在中国维吾尔族女性人口。选择3个SNPs（PGFRs 8019391、PGFRs 2268615和TNFAIP 2 rs710100）进行基因分型，以评估PGFs和TNFAIP 2多态性与CC易感性的可能关联。结果PGFrs 2268615（OR = 1.39，95%CI = 1.04- 1.86，p = 0.024）和TNFAIP 2 rs710100（OR = 1.44，95%CI =1.07- 1.95，p = 0.018）基因多态性与CC的发病风险相关。此外，PGFrs 8019391的T等位基因在III ~ IV期患者中的表达率高于I ~ II期患者（OR = 2.17，p = 4.58 × 10− 4）。结论PGFRs 2268615和TNFAIP 2 rs710100多态性可能是CC易感性的危险因素，并可能增加CC的发病风险。
BackgroundPGFandTNFAIP2are important angiogenic factors, which were abnormal expression in cervical cancer (CC). However, there is currently no report investigating the relationship ofPGFandTNFAIP2gene polymorphisms to CC risk.MethodsWe conducted a case-control study of 342 CC patients and 498 cancer-free controls in a Chinese Uygur female population. Three SNPs (PGFrs8019391,PGFrs2268615, andTNFAIP2rs710100) were selected and genotyped to assess the possible association ofPGFandTNFAIP2polymorphisms with CC susceptibility. Logistic regression analysis adjusted by age was used.ResultsPGFrs2268615 (OR = 1.39, 95% CI = 1.04–1.86,p = 0.024) andTNFAIP2rs710100 (OR = 1.44, 95% CI =1.07–1.95,p = 0.018) polymorphisms were associated with the increased risk of CC. Moreover, T allele ofPGFrs8019391 was highly represented in patients with stage III–IV compared with stage I-II (OR = 2.17,p = 4.58 × 10− 4). MDR analysis revealed a positive interaction between the SNPs.ConclusionOur data indicated thatPGFrs2268615, andTNFAIP2rs710100 polymorphisms might be risk factors for CC susceptibility, which contributed to the increased risk of CC.Trial registrationNot applicable.
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