Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy.
Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy.
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DOI：
10.1007/s10555-010-9216-5
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发表时间：
2010-03
影响因子：
9.2
通讯作者：
Shay, Jerry W.
中科院分区：
文献类型：
--
作者：
Sullivan, James P.;Minna, John D.;Shay, Jerry W.
首先在白血病中发现具有干细胞特征的罕见肿瘤细胞，然后在实体瘤中发现，这已经成为癌症研究的一个重要领域。已经确定，这些干细胞样的肿瘤细胞被称为癌症干细胞，是肿瘤中驱动疾病进展和转移的主要细胞成分。除了干细胞样的自我更新和分化能力外，癌症干细胞还富含对传统放射治疗和化疗具有抵抗力的细胞。这一新的肿瘤生长模式的直接影响不仅需要重新评估肿瘤是如何启动的，而且还需要重新评估应该如何监测和治疗肿瘤。然而，尽管癌症干细胞在乳腺癌、脑癌和结肠癌等实体肿瘤中的研究步伐相对较快，但在肺癌方面的类似进展仍然受到阻碍，部分原因是对肺上皮干细胞层次结构的不完全了解和疾病的复杂异质性。在这篇综述中，我们对正常和恶性肺干细胞在肿瘤发展中的作用、肺癌干细胞特性的研究进展以及肺癌干细胞自我更新的治疗靶向途径的可能性进行了重要的综述。
The discovery of rare tumor cells with stem cell features first in leukemia and later in solid tumors has emerged as an important area in cancer research. It has been determined that these stem-like tumor cells, termed cancer stem cells, are the primary cellular component within a tumor that drives disease progression and metastasis. In addition to their stem-like ability to self-renew and differentiate, cancer stem cells are also enriched in cells resistant to conventional radiation therapy and to chemotherapy. The immediate implications of this new tumor growth paradigm not only require a re-evaluation of how tumors are initiated, but also on how tumors should be monitored and treated. However, despite the relatively rapid pace of cancer stem cell research in solid tumors such as breast, brain, and colon cancers, similar progress in lung cancer remains hampered in part due to an incomplete understanding of lung epithelial stem cell hierarchy and the complex heterogeneity of the disease. In this review, we provide a critical summary of what is known about the role of normal and malignant lung stem cells in tumor development, the progress in characterizing lung cancer stem cells and the potential for therapeutically targeting pathways of lung cancer stem cell self-renewal.
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影响因子：
5.2
作者：
Bar, Eli E.;Chaudhry, Aneeka;Eberharta, Charles G.
通讯作者：
Eberharta, Charles G.
影响因子：
8
作者：
Dang, TP;Eichenberger, S;Carbone, DP
通讯作者：
Carbone, DP
DOI：
10.1165/ajrcmb/2.1.51
发表时间：
1990-01-01
影响因子：
6.4
作者：
BREUER, R;ZAJICEK, G;SNIDER, GL
通讯作者：
SNIDER, GL
DOI：
10.1164/ajrccm.157.6.9707011
发表时间：
1998-06-01
影响因子：
24.7
作者：
Boers, JE;Ambergen, AW;Thunnissen, FBJM
通讯作者：
Thunnissen, FBJM
DOI：
10.1073/pnas.0603806103
发表时间：
2006-08-01
影响因子：
11.1
作者：
Chute, John P.;Muramoto, Garrett G.;McDonnell, Donald P.
通讯作者：
McDonnell, Donald P.