The functional universe of membrane contact sites.

The functional universe of membrane contact sites.
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DOI:
10.1038/s41580-019-0180-9
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发表时间:
2020-01
期刊:
Nature reviews. Molecular cell biology
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其他
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细胞器将真核细胞区室化,增强它们对环境和发育变化的反应能力。细胞器交流和整合其活动的一种方式是形成密切接触,通常称为“膜接触位点”(MCS)。在过去的十年中,对MCSs的兴趣急剧增长,因为很明显,它们无处不在,并且在细胞中的关键作用比最初想象的要广泛得多。事实上,现在已经报道了MCSs在细胞内信号传导(特别是钙信号传导、活性氧信号传导和脂质信号传导)、自噬、脂质代谢、膜动力学、细胞应激反应和细胞器运输和生物发生中的功能。
Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to environmental and developmental changes. One way in which organelles communicate and integrate their activities is by forming close contacts, often called ‘membrane contact sites’ (MCSs). Interest in MCSs has grown dramatically in the past decade as it is has become clear that they are ubiquitous and have a much broader range of critical roles in cells than was initially thought. Indeed, functions for MCSs in intracellular signalling (particularly calcium signalling, reactive oxygen species signalling and lipid signalling), autophagy, lipid metabolism, membrane dynamics, cellular stress responses and organelle trafficking and biogenesis have now been reported.
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