BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.
BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions.
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DOI：
10.1126/scitranslmed.aam7816
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发表时间：
2017-12-06
影响因子：
17.1
通讯作者：
Simons M
中科院分区：
文献类型：
--
作者：
Fard MK;van der Meer F;Sánchez P;Cantuti-Castelvetri L;Mandad S;Jäkel S;Fornasiero EF;Schmitt S;Ehrlich M;Starost L;Kuhlmann T;Sergiou C;Schultz V;Wrzos C;Brück W;Urlaub H;Dimou L;Stadelmann C;Simons M
对脑功能和疾病的研究依赖于神经细胞类型的精确分类。少突胶质细胞谱系的细胞在形态上差异很大，但迄今为止，准确鉴定仅可能用于人类中的少突胶质细胞祖细胞和成熟的少突胶质细胞。我们发现，乳腺癌扩增序列1（BCAS1）的表达确定了小鼠和人脑中的少突胶质细胞亚群。这些细胞是新形成的髓鞘化少突胶质细胞，其与少突胶质细胞祖细胞和成熟的少突胶质细胞分离，并标记发育和成人中活跃髓鞘形成的区域。我们发现，BCAS1+少突胶质细胞仅限于胎儿和出生后早期的人类白色物质，但仍然在皮质灰质，直到老年。BCAS1+少突胶质细胞在实验性脱髓鞘后重新形成，并在多发性硬化症（MS）患者的慢性白色病变中发现，甚至在晚期疾病患者的子集中也发现。我们的工作确定了一种方法来映射健康和疾病中正在进行的髓鞘形成，并提出了MS髓鞘再生治疗的潜在细胞靶点。
Investigations into brain function and disease depend on the precise classification of neural cell types. Cells of the oligodendrocyte lineage differ greatly in their morphology, but accurate identification has thus far only been possible for oligodendrocyte progenitor cells and mature oligodendrocytes in humans. We find that breast carcinoma amplified sequence 1 (BCAS1) expression identifies an oligodendroglial subpopulation in the mouse and human brain. These cells are newly formed, myelinating oligodendrocytes that segregate from oligodendrocyte progenitor cells and mature oligodendrocytes and mark regions of active myelin formation in development and in the adult. We find that BCAS1+ oligodendrocytes are restricted to the fetal and early postnatal human white matter but remain in the cortical gray matter until old age. BCAS1+ oligodendrocytes are reformed after experimental demyelination and found in a proportion of chronic white matter lesions of patients with multiple sclerosis (MS) even in a subset of patients with advanced disease. Our work identifies a means to map ongoing myelin formation in health and disease and presents a potential cellular target for remyelination therapies in MS.
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影响因子：
3.5
作者：
Leone, DP;Genoud, S;Suter, U
通讯作者：
Suter, U
影响因子：
11.2
作者：
PRINEAS, JW;BARNARD, RO;CHO, ES
通讯作者：
CHO, ES
影响因子：
158.5
作者：
Chang, A;Tourtellotte, WW;Trapp, BD
通讯作者：
Trapp, BD
影响因子：
20.1
作者：
Nakamura, Tomoki;Colbert, Melissa C.;Robbins, Jeffrey
通讯作者：
Robbins, Jeffrey
影响因子：
25
作者：
Madisen L;Zwingman TA;Sunkin SM;Oh SW;Zariwala HA;Gu H;Ng LL;Palmiter RD;Hawrylycz MJ;Jones AR;Lein ES;Zeng H
通讯作者：
Zeng H