B cells enhance early innate immune responses during bacterial sepsis.
B cells enhance early innate immune responses during bacterial sepsis.
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DOI：
10.1084/jem.20101715
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发表时间：
2011-08-01
期刊：
影响因子：
--
通讯作者：
Moldawer LL
中科院分区：
文献类型：
--
作者：
Kelly-Scumpia KM;Scumpia PO;Weinstein JS;Delano MJ;Cuenca AG;Nacionales DC;Wynn JL;Lee PY;Kumagai Y;Efron PA;Akira S;Wasserfall C;Atkinson MA;Moldawer LL
I型干扰素应答性B细胞提供针对细菌性脓毒症的早期保护。微生物激活模式识别受体以启动适应性免疫。T细胞影响对病毒感染的早期先天性炎症反应，但激活和抑制都已得到证实。我们发现B细胞在细菌性脓毒症的早期先天性免疫反应中的新作用。我们证明Rag 1 −/−小鼠在脓毒症期间表现出早期炎症反应不足和存活率降低。有趣的是，B细胞缺陷或抗CD 20 B细胞耗尽的小鼠，而不是α/β T细胞缺陷的小鼠，显示出减少的炎性细胞因子和趋化因子的产生，并降低脓毒症后的存活率。用野生型（WT）小鼠血清治疗B细胞缺陷小鼠和用B细胞补充Rag 1-/-小鼠均可改善败血症生存率，这表明B细胞在败血症结局中具有抗体非依赖性和抗体依赖性作用。在脓毒症期间，边缘区和滤泡B细胞通过I型干扰素（IFN-I）受体（IFN-α/β受体[IFNAR]）激活，用WT（而非IFNAR-/-）补充Rag 1-/-小鼠B细胞可改善IFN-I依赖性和非依赖性早期细胞因子应答。给B细胞缺陷小鼠补充IFN-1依赖性趋化因子CXCL 10也足以提高脓毒症存活率。本研究确定了一种新的作用，IFN-I激活的B细胞在细菌性脓毒症的保护性早期先天免疫反应。
Type I interferon–responsive B cells provide early protection against bacterial sepsis. Microbes activate pattern recognition receptors to initiate adaptive immunity. T cells affect early innate inflammatory responses to viral infection, but both activation and suppression have been demonstrated. We identify a novel role for B cells in the early innate immune response during bacterial sepsis. We demonstrate that Rag1−/− mice display deficient early inflammatory responses and reduced survival during sepsis. Interestingly, B cell–deficient or anti-CD20 B cell–depleted mice, but not α/β T cell–deficient mice, display decreased inflammatory cytokine and chemokine production and reduced survival after sepsis. Both treatment of B cell–deficient mice with serum from wild-type (WT) mice and repletion of Rag1−/− mice with B cells improves sepsis survival, suggesting antibody-independent and antibody-dependent roles for B cells in the outcome to sepsis. During sepsis, marginal zone and follicular B cells are activated through type I interferon (IFN-I) receptor (IFN-α/β receptor [IFNAR]), and repleting Rag1−/− mice with WT, but not IFNAR−/−, B cells improves IFN-I–dependent and –independent early cytokine responses. Repleting B cell–deficient mice with the IFN-I–dependent chemokine, CXCL10 was also sufficient to improve sepsis survival. This study identifies a novel role for IFN-I–activated B cells in protective early innate immune responses during bacterial sepsis.
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适应性免疫细胞缓和最初的先天反应。
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
3.1
作者：
Enoh, Victor T.;Lin, Scott H.;Sherwood, Edward R.
通讯作者：
Sherwood, Edward R.
影响因子：
24.5
作者：
Busse, M.;Traeger, T.;Broeker, B. M.
通讯作者：
Broeker, B. M.
DOI：
10.1084/jem.189.10.1639
发表时间：
1999-05-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan OT;Hannum LG;Haberman AM;Madaio MP;Shlomchik MJ
通讯作者：
Shlomchik MJ
影响因子：
56.9
作者：
Macpherson, AJ;Gatto, D;Zinkernagel, RM
通讯作者：
Zinkernagel, RM