Identification and targeting of cancer stem cells.
Identification and targeting of cancer stem cells.
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DOI：
10.1002/bies.200900058
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发表时间：
2009-10
期刊：
影响因子：
4
通讯作者：
Frank, Markus H.
中科院分区：
文献类型：
--
作者：
Schatton, Tobias;Frank, Natasha Y.;Frank, Markus H.
癌症干细胞（CSC）代表分级组织的肿瘤中的恶性细胞亚群，其能够选择性地进行肿瘤起始和自我更新，并通过分化产生大量非致瘤性癌细胞后代群体。在竞争性肿瘤发展模型中，使用分子定义的癌症亚群的标志物特异性遗传谱系追踪，已经产生了癌症群体中存在前瞻性可识别CSC的有力证据。此外，已经发现了将CSC与癌症治疗抗性和临床肿瘤进展联系起来的新机制和关系。重要的是，CSC概念的潜在治疗效用的原理证明最近已经通过证明通过前瞻性分子标记物选择性杀死CSC可以抑制肿瘤生长来提供。在此，我们回顾了这些新的和相关的研究进展，并讨论了潜在的策略，CSC靶向治疗的耐药机制和分子途径的背景下，优先在CSC。
Cancer stem cells (CSC) represent malignant cell subsets in hierarchically organized tumors, which are selectively capable of tumor initiation and self-renewal and give rise to bulk populations of non-tumorigenic cancer cell progeny through differentiation. Robust evidence for the existence of prospectively identifiable CSC among cancer bulk populations has been generated using marker-specific genetic lineage tracking of molecularly defined cancer subpopulations in competitive tumor development models. Moreover, novel mechanisms and relationships have been discovered that link CSC to cancer therapeutic resistance and clinical tumor progression. Importantly, proof-of-principle for the potential therapeutic utility of the CSC concept has recently been provided by demonstrating that selective killing of CSC through a prospective molecular marker can inhibit tumor growth. Herein, we review these novel and translationally relevant research developments and discuss potential strategies for CSC-targeted therapy in the context of resistance mechanisms and molecular pathways preferentially operative in CSC.
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影响因子：
82.9
作者：
Castor, A;Nilsson, L;Jacobsen, SEW
通讯作者：
Jacobsen, SEW
影响因子：
15.9
作者：
Bellodi, Cristian;Lidonnici, Maria Rosa;Calabretta, Bruno
通讯作者：
Calabretta, Bruno
影响因子：
20.3
作者：
Cox, CV;Evely, RS;Blair, A
通讯作者：
Blair, A
DOI：
10.1073/pnas.0703478104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Dalerba, Piero;Dylla, Scott J.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.
影响因子：
64.8
作者：
BRUCE, WR;VANDERGA.H
通讯作者：
VANDERGA.H