Physiological and modeling evidence for focal transcranial electrical brain stimulation in humans: a basis for high-definition tDCS.
Physiological and modeling evidence for focal transcranial electrical brain stimulation in humans: a basis for high-definition tDCS.
复制标题
DOI：
10.1016/j.neuroimage.2013.01.042
复制
发表时间：
2013-07-01
期刊：
影响因子：
5.7
通讯作者：
Bikson, Marom
中科院分区：
文献类型：
--
作者：
Edwards, Dylan;Cortes, Mar;Datta, Abhishek;Minhas, Preet;Wassermann, Eric M.;Bikson, Marom
经颅直流电刺激（tDCS）是一种非侵入性、低成本、耐受性良好的技术，可持久调节皮质兴奋性。tDCS的行为和治疗结果与目标大脑区域有关，但几乎没有证据表明电流按预期到达大脑。我们的目标是：（1）验证用于估计人体经颅刺激中皮质电场的计算模型，以及（2）使用4×1环电极配置，通过新型高清tDCS（HD-tDCS）头皮导联评估皮质电场的幅度和分布。在3名健康成人中，使用4×1导联（4×阴极，围绕单个中央阳极;导联半径约3 cm）在初级运动皮层（M1）上进行经颅电刺激（TES），强度足以引起手部的离散肌肉抽搐。使用基于MRI的个体化模型计算M1中的估计电流分布，并与观察到的受试者运动反应进行比较。通过刺激运动皮层以及运动皮层的前部和后部来量化反应幅度。在每种情况下，模型数据与受试者的运动反应一致。比较了每例受试者TES和tDCS的4×1导联估计皮质电场（面积、幅度、方向）。我们提供了人类的直接证据，即具有4×1环配置的TES可以激活运动皮层，并且电流基本上不会扩散到刺激区域之外。计算模型预测，使用4×1环配置的TES和tDCS波形在皮质中产生具有可比总电流分布的电场，并且优先定向正常（向内）电流。电流输送和局灶性的建模和实验数据的一致性支持使用HD-tDCS 4×1环导联进行皮质靶向神经调节。
Transcranial Direct Current Stimulation (tDCS) is a non-invasive, low-cost, well-tolerated technique producing lasting modulation of cortical excitability. Behavioral and therapeutic outcomes of tDCS are linked to the targeted brain regions, but there is little evidence that current reaches the brain as intended. We aimed to: (1) validate a computational model for estimating cortical electric fields in human transcranial stimulation, and (2) assess the magnitude and spread of cortical electric field with a novel High-Definition tDCS (HD-tDCS) scalp montage using a 4×1-Ring electrode configuration. In three healthy adults, Transcranial Electrical Stimulation (TES) over primary motor cortex (M1) was delivered using the 4×1 montage (4× cathode, surrounding a single central anode; montage radius ~3 cm) with sufficient intensity to elicit a discrete muscle twitch in the hand. The estimated current distribution in M1 was calculated using the individualized MRI-based model, and compared with the observed motor response across subjects. The response magnitude was quantified with stimulation over motor cortex as well as anterior and posterior to motor cortex. In each case the model data were consistent with the motor response across subjects. The estimated cortical electric fields with the 4×1 montage were compared (area, magnitude, direction) for TES and tDCS in each subject. We provide direct evidence in humans that TES with a 4×1-Ring configuration can activate motor cortex and that current does not substantially spread outside the stimulation area. Computational models predict that both TES and tDCS waveforms using the 4×1-Ring configuration generate electric fields in cortex with comparable gross current distribution, and preferentially directed normal (inward) currents. The agreement of modeling and experimental data for both current delivery and focality support the use of the HD-tDCS 4×1-Ring montage for cortically targeted neuromodulation.
登录
查看更多内容
DOI：
10.1016/0013-4694(88)90062-4
发表时间：
1988-05-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
COHEN, LG;HALLETT, M
通讯作者：
HALLETT, M
影响因子：
5.5
作者：
DAY, BL;DRESSLER, D;THOMPSON, PD
通讯作者：
THOMPSON, PD
影响因子：
14.5
作者：
Hummel, F;Celnik, P;Cohen, LG
通讯作者：
Cohen, LG
影响因子：
7.7
作者：
Datta, Abhishek;Bansal, Varun;Diaz, Julian;Patel, Jinal;Reato, Davide;Bikson, Marom
通讯作者：
Bikson, Marom
影响因子：
3.5
作者：
Gabriel, S;Lau, RW;Gabriel, C
通讯作者：
Gabriel, C