A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease.
A Tale of Two Toxins: Helicobacter Pylori CagA and VacA Modulate Host Pathways that Impact Disease.
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DOI：
10.3389/fmicb.2010.00115
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发表时间：
2010
影响因子：
5.2
通讯作者：
Merrell DS
中科院分区：
文献类型：
--
作者：
Jones KR;Whitmire JM;Merrell DS
幽门螺杆菌（Helicobacter pylori，Hp）是一种致病性细菌，在全球50%以上的人口中定植，给人类带来巨大的医疗负担。H.幽门螺杆菌感染与各种疾病有关，如胃炎、消化性溃疡和两种形式的胃癌：胃腺癌和粘膜相关淋巴组织淋巴瘤。这种关联代表了癌症发展的一种新模式;幽门螺杆菌是目前唯一被确认为致癌物的细菌。因此，已经进行了大量的研究来鉴定细菌因子和失调的宿主细胞途径，这些因子和失调的宿主细胞途径是导致疾病进展到更严重的疾病状态的原因。细胞毒素相关基因A（cytotoxin-associated gene A，CagA）和空泡细胞毒素A（vacuolating cytotoxin A，VacA）是H. pylori，分别这两种毒力因子都是多态性的，并且影响多种宿主细胞途径。这些综合因素很容易导致人群中疾病严重程度的差异，因为不同的CagA和VacA等位基因不同地靶向某些途径。在这里，我们强调了这些重要毒素所针对的不同类型的细胞途径和过程。
Helicobacter pylori is a pathogenic bacterium that colonizes more than 50% of the world's population, which leads to a tremendous medical burden. H. pylori infection is associated with such varied diseases as gastritis, peptic ulcers, and two forms of gastric cancer: gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma. This association represents a novel paradigm for cancer development; H. pylori is currently the only bacterium to be recognized as a carcinogen. Therefore, a significant amount of research has been conducted to identify the bacterial factors and the deregulated host cell pathways that are responsible for the progression to more severe disease states. Two of the virulence factors that have been implicated in this process are cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA), which are cytotoxins that are injected and secreted by H. pylori, respectively. Both of these virulence factors are polymorphic and affect a multitude of host cellular pathways. These combined facts could easily contribute to differences in disease severity across the population as various CagA and VacA alleles differentially target some pathways. Herein we highlight the diverse types of cellular pathways and processes targeted by these important toxins.
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影响因子：
6.7
作者：
Botham, Crystal M.;Wandler, Anica M.;Guillemin, Karen
通讯作者：
Guillemin, Karen
DOI：
10.1084/jem.191.1.115
发表时间：
2000-01-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Allen LA;Schlesinger LS;Kang B
通讯作者：
Kang B
影响因子：
9.4
作者：
Atherton, JC;Cover, TL;Blaser, MJ
通讯作者：
Blaser, MJ
影响因子：
29.4
作者：
Argent, RH;Kidd, M;Atherton, JC
通讯作者：
Atherton, JC
影响因子：
5.7
作者：
Ben Mansour K;Fendri C;Zribi M;Masmoudi A;Labbene M;Fillali A;Ben Mami N;Najjar T;Meherzi A;Sfar T;Burucoa C
通讯作者：
Burucoa C