Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention.
Developmental windows of breast cancer risk provide opportunities for targeted chemoprevention.
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DOI：
10.1016/j.yexcr.2013.04.018
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发表时间：
2013-07-01
影响因子：
3.7
通讯作者：
Schedin, Pepper
中科院分区：
文献类型：
--
作者：
Martinson, Holly A.;Lyons, Traci R.;Giles, Erin D.;Borges, Virginia F.;Schedin, Pepper
乳腺癌问题的严重性要求研究人员积极研究预防策略。然而，目前的一些障碍降低了乳腺癌预防的可行性。这些障碍包括无法在个体水平上准确预测未来的乳腺癌诊断，需要更好地了解何时实施干预措施，最佳治疗持续时间的不确定性以及与目前批准的化学预防疗法相关的负面副作用。尽管如此，乳腺独特的生物学特性及其出生后发育和条件性终末分化可能允许解决许多这些障碍。具体而言，已经确定了乳腺癌风险的生命周期特定窗口，这些窗口可能适用于降低风险的策略。在这里，我们主张预防研究集中在两个生命周期的风险窗口：产后乳腺退化和围绝经期。我们提供的证据表明，这些窗口是非常适合有针对性的，有限的持续时间的治疗。这些方法可以相应地预防产后和绝经后乳腺癌。
The magnitude of the breast cancer problem implores researchers to aggressively investigate prevention strategies. However, several barriers currently reduce the feasibility of breast cancer prevention. These barriers include the inability to accurately predict future breast cancer diagnosis at the individual level, the need for improved understanding of when to implement interventions, uncertainty with respect to optimal duration of treatment, and negative side effects associated with currently approved chemoprevention therapies. None-the-less, the unique biology of the mammary gland, with its postnatal development and conditional terminal differentiation, may permit the resolution of many of these barriers. Specifically, lifecycle-specific windows of breast cancer risk have been identified that may be amenable to risk-reducing strategies. Here, we argue for prevention research focused on two of these lifecycle windows of risk: postpartum mammary gland involution and peri-menopause. We provide evidence that these windows are highly amenable to targeted, limited duration treatments. Such approaches could result in the prevention of postpartum and postmenopausal breast cancers, correspondingly.
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影响因子：
50.3
作者：
Crawford, YG;Gauthier, ML;Tlsty, TD
通讯作者：
Tlsty, TD
影响因子：
5
作者：
Chie, WC;Hsieh, CC;MacMahon, B
通讯作者：
MacMahon, B
DOI：
10.1016/0027-5107(95)00128-x
发表时间：
1995-12-01
影响因子：
2.3
作者：
Adami, HO;Persson, I;Trichopoulos, D
通讯作者：
Trichopoulos, D
影响因子：
0.7
作者：
Borges, Virginia F.;Schedin, Pepper
通讯作者：
Schedin, Pepper
影响因子：
11.2
作者：
Gupta, Piyush B.;Proia, David;Kuperwasser, Charlotte
通讯作者：
Kuperwasser, Charlotte