Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders.
Why Are Some People with Lower Urinary Tract Symptoms (LUTS) Depressed? New Evidence That Peripheral Inflammation in the Bladder Causes Central Inflammation and Mood Disorders.
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DOI：
10.3390/ijms24032821
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发表时间：
2023-02-01
影响因子：
5.6
通讯作者：
Purves, J. Todd
中科院分区：
文献类型：
--
作者：
Hughes Jr, Francis M. M.;Odom, Michael R. R.;Cervantes, Anissa;Livingston, Austin J. J.;Purves, J. Todd
长期以来，传闻证据表明，下尿路症状（LUTS）患者发生情绪障碍（如抑郁和焦虑）的比率高于一般人群，最近的前瞻性研究证实了这一联系。我们对LUTS潜在疾病的理解的突破性进展表明，许多疾病具有实质性的炎症成分，最近我们在理解这种炎症是如何触发方面取得了很大进展。与此同时，对情绪障碍的研究发现，许多情绪障碍与中枢神经炎症有关，最明显的是海马体。令人兴奋的是，对以外周炎症为特征的其他疾病的研究表明，它们可以引发中枢神经炎症和情绪障碍。在这篇综述中，我们讨论了目前的证据联系LUTS情绪障碍，其可能的双向，炎症作为一种常见的机制。我们还回顾了炎症和抑郁症的现代理论。最后，我们讨论了令人兴奋的新的动物研究，这些研究直接将两种以广泛的膀胱炎症（环磷酰胺诱导的出血性膀胱炎和膀胱出口梗阻）为特征的膀胱疾病与神经炎症和抑郁症联系起来。最后，我们讨论了可能的机制，外周炎症转化为中枢神经炎症与精神问题。
Anecdotal evidence has long suggested that patients with lower urinary tract symptoms (LUTS) develop mood disorders, such as depression and anxiety, at a higher rate than the general population and recent prospective studies have confirmed this link. Breakthroughs in our understanding of the diseases underlying LUTS have shown that many have a substantial inflammatory component and great strides have been made recently in our understanding of how this inflammation is triggered. Meanwhile, studies on mood disorders have found that many are associated with central neuroinflammation, most notably in the hippocampus. Excitingly, work on other diseases characterized by peripheral inflammation has shown that they can trigger central neuroinflammation and mood disorders. In this review, we discuss the current evidence tying LUTS to mood disorders, its possible bidirectionally, and inflammation as a common mechanism. We also review modern theories of inflammation and depression. Finally, we discuss exciting new animal studies that directly tie two bladder conditions characterized by extensive bladder inflammation (cyclophosphamide-induced hemorrhagic cystitis and bladder outlet obstruction) to neuroinflammation and depression. We conclude with a discussion of possible mechanisms by which peripheral inflammation is translated into central neuroinflammation with the resulting psychiatric concerns.
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影响因子：
2.6
作者：
Caiaffo V;Oliveira BD;de Sá FB;Evêncio Neto J
通讯作者：
Evêncio Neto J
影响因子：
3.7
作者：
通讯作者：
--
影响因子：
2.9
作者：
Belayev, L;Busto, R;Ginsberg, MD
通讯作者：
Ginsberg, MD
专门的促解决介质：感染和炎症的内源性调节剂。
DOI：
10.1038/nri.2015.4
发表时间：
2016-01
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Basil MC;Levy BD
通讯作者：
Levy BD
影响因子：
2.6
作者：
Staskin, D. R.;Rosenberg, M. T.;Dahl, N. V.;Polishuk, P. V.;Zinner, N. R.
通讯作者：
Zinner, N. R.