Simple codes versus efficient codes
Simple codes versus efficient codes
复制标题
简单代码与高效代码
DOI：
10.1016/0959-4388(95)80032-8
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发表时间：
1995
影响因子：
5.7
通讯作者：
William R. Softky
中科院分区：
文献类型：
--
作者：
William R. Softky
信息传输是皮层神经元的重要功能，因此可以想象，它们已经进化到以低噪声和高时间精度有效地传输信息。这种精确度与各种模拟神经元活动的工作模型产生的输出一致，从简单的积分和激发模型到逼真神经元的精细数值模拟。但是我们目前无法将这些数据与体内神经元详细的尖峰产生机制相匹配，这使得我们在解释其尖峰代码的各个组成部分的重要性方面有很大的自由度。一个极端的假设，即“简单”模型，是每个神经元都是嘈杂和缓慢的，执行简单的计算并传输少量信息。另一个与之竞争的假说是“有效”模型，它假设神经元通过精确、复杂的单次计算来传输大量信息。这两种假设与现有数据基本一致。只有发展新的测量技术，才能解决这一矛盾。新的测量技术将允许人们直接研究使神经元有效的特性，也就是说，能够测量最薄树突内部高度瞬态的局部事件，这是目前实验无法达到的。
Transmission of information is an important function of cortical neurons, so it is conceivable that they have evolved to transmit information efficiently, with low noise and high temporal precision. Such precision is consistent with the output generated by various working models that mimick neuronal activity, from simple integrate-and-fire models to elaborate numerical simulations of realistic-looking neurons. But our current inability to match this data with neurons' detailed spike-generating mechanisms in vivo allows us a wide latitude in interpreting the significance of the various components of their spike code. One extreme hypothesis, the ‘simple’ model, is that each neuron is noisy and slow, performing a simple computation and transmitting a small amount of information. A competing hypothesis, the ‘efficient’ model, postulates that a neuron transmits large amounts of information through precise, complex, single-spike computations. Both hypotheses are broadly consistent with the available data. The conflict may only be resolved with the development of new measurement techniques that will allow one to investigate directly the properties that make a neuron efficient — that is, to be able to measure highly transient, localized events inside the thinnest dendrites, which are currently experimentally inaccessible.
DOI：
10.1073/pnas.86.7.2473
发表时间：
1989-04-01
影响因子：
11.1
作者：
HUGUENARD, JR;HAMILL, OP;PRINCE, DA
通讯作者：
PRINCE, DA
影响因子：
2.5
作者：
THEUNISSEN, FE;MILLER, JP
通讯作者：
MILLER, JP