Sex and race define the effects of adverse childhood experiences on self-reported BMI and metabolic health biomarkers.
Sex and race define the effects of adverse childhood experiences on self-reported BMI and metabolic health biomarkers.
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性别和种族定义了不良童年经历对自我报告的BMI和代谢健康生物标志物的影响。
DOI：
10.1186/s13293-022-00439-x
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发表时间：
2022-06-15
影响因子：
7.9
通讯作者：
中科院分区：
文献类型：
--
作者：
不良童年经历（ACE）是慢性疾病的独立危险因素，包括2型糖尿病，中风和缺血性心脏病。然而，ACE考虑性别和种族的影响并不经常报告的队列显示多种族组成，权力，以评估对代表性不足的人群的影响。确定性别和种族如何影响南方社区队列研究（2012-2015）中合并和个体ACE与代谢健康生物标志物的关联。分析了在第二次随访期间进行的ACE调查的自我报告数据，该队列由超过60%的黑人受试者组成，总体平均年龄为60岁。在黑人和白色女性中，BMI随着累积ACE而稳步增加，但在≥ 4次ACE的白色男性中保持相对稳定。相反，黑人男性显示ACE和BMI之间呈负相关。代谢结果的二次分析显示，黑人受试者的身体虐待与腰围增加4.85 cm相关。ACE超过4个的个体的总胆固醇增加。此外，HbA 1c升高与黑人女性的情感虐待和母亲虐待以及白色女性的性虐待相关。无论种族如何，BMI与女性的累积ACE密切相关，而腰围与黑人个体的ACE密切相关，这与BMI降低相结合可能表明黑人男性的中心性肥胖增加。我们的研究表明，性别和种族影响某些ACE损害代谢健康的贡献。在线版本包含补充材料，可通过10.1186/s13293-022-00439-x获得。这项研究显示了ACE在一个具有独特的多种族组成的队列中的影响，并且有足够的把握度来评估这些影响在代表性不足的人群中的作用。无论种族如何，女性的身体肥胖与累积ACE密切相关。只有黑人男性表现出累积ACE和身体肥胖之间的负相关。然而，黑人个体表现出增加腰围与身体虐待表明ACE的影响增加中心性肥胖和代谢风险在这一人群中。特定的不良经历似乎会改变代谢生物标志物，其独特的特征取决于性别或种族。对这些关联的进一步研究对于开发更有效的预防性和个性化药物以减少健康差距至关重要。在线版本包含补充材料，可通过10.1186/s13293-022-00439-x获得。
Adverse childhood experiences (ACEs) are an independent risk factor for chronic diseases, including type 2 diabetes, stroke and ischemic heart disease. However, the effect of ACEs considering sex and race are not often reported in cohorts showing multiracial composition, with power to evaluate effects on underrepresented populations. To determine how sex and race affected the association of combined and individual ACEs with metabolic health biomarkers in the Southern Community Cohort Study (2012–2015). Self-reported data were analyzed from ACE surveys performed during the second follow-up of a cohort comprised by over 60% of Black subjects and with an overall mean age of 60 years. BMI steadily increased with cumulative ACEs among Black and White women, but remained relatively stable in White men with ≥ 4 ACEs. Contrary, Black men showed an inverse association between ACE and BMI. Secondary analysis of metabolic outcomes showed that physical abuse was correlated with a 4.85 cm increase in waist circumference in Black subjects. Total cholesterol increased among individuals with more than 4 ACEs. In addition, increases in HbA1c were associated with emotional and maternal abuse in Black women and sexual abuse in White women. BMI is strongly associated with cumulative ACEs in women regardless the race, while waist circumference is strongly associated with ACEs in Black individuals, which combined with reduced BMI may indicate increased central adiposity in Black men. Our study suggests that sex and race influence the contribution of certain ACEs to impair metabolic health. The online version contains supplementary material available at 10.1186/s13293-022-00439-x. This study shows the effects of ACEs in a cohort with a unique multiracial composition and enough power to evaluate these effects in underrepresented populations. Body adiposity is strongly associated with cumulative ACEs in women regardless of race. Only Black men displayed a negative correlation between cumulative ACEs and body adiposity. However, Black individuals showed an increased waist circumference with physical abuse suggesting an effect of ACEs on increased central adiposity and metabolic risk in this population. Specific adverse experiences seem to alter metabolic biomarkers with a unique signature depending on sex or race. Further investigation of these associations is critical to developing a more effective preventive and personalized medicine to reduce health disparities. The online version contains supplementary material available at 10.1186/s13293-022-00439-x.
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DOI：
10.1111/obr.12358
发表时间：
2016-03
期刊：
Obesity reviews : an official journal of the International Association for the Study of Obesity
影响因子：
--
作者：
Heymsfield SB;Peterson CM;Thomas DM;Heo M;Schuna JM Jr
通讯作者：
Schuna JM Jr
影响因子：
3.6
作者：
Goldstein E;Topitzes J;Miller-Cribbs J;Brown RL
通讯作者：
Brown RL
影响因子：
8.3
作者：
De Hert M;Detraux J;Vancampfort D
通讯作者：
Vancampfort D
影响因子：
1.4
作者：
Hargreaves, Margaret K.;Mouton, Charles P.;Blot, William J.
通讯作者：
Blot, William J.
影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.