Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons.
Polypyrrole-coated electrodes for the delivery of charge and neurotrophins to cochlear neurons.
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DOI：
10.1016/j.biomaterials.2009.01.015
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发表时间：
2009-05
期刊：
影响因子：
14
通讯作者：
O'Leary, Stephen J.
中科院分区：
文献类型：
--
作者：
Richardson, Rachael T.;Wise, Andrew K.;Thompson, Brianna C.;Flynn, Brianna O.;Atkinson, Patrick J.;Fretwell, Nicole J.;Fallon, James B.;Wallace, Gordon G.;Shepherd, Rob K.;Clark, Graeme M.;O'Leary, Stephen J.
关键词：
感音神经性听力损失与螺旋神经节神经元（SGN）的逐渐变性有关，影响人工耳蜗植入的听力结果。将神经营养因子递送到耳蜗和来自耳蜗植入物的电刺激相结合保护SGN，促进了对神经营养因子洗脱聚合物电极涂层的研究。将含有神经营养素-3的导电聚吡咯/对甲苯磺酸盐（Ppy/pTS/NT 3）施加到1.7mm 2的人工耳蜗电极。PPy/pTS/NT 3涂覆的电极阵列储存2ng NT 3，并且在电刺激下释放0.1ng/天。豚鼠经氨基糖苷类药物致聋2周后植入Ppy/pTS或Ppy/pTS/NT 3电极阵列。这些豚鼠的一个亚组的电极被电刺激8小时/天，持续2周。植入Ppy/pTS涂层电极的豚鼠耳蜗中SGN丢失，表明电极插入损伤。然而，与未植入耳蜗和植入Ppy/pTS/NT 3涂层电极的动物相比，植入电刺激Ppy/pTS/NT 3涂层电极的豚鼠的电诱发听觉脑干反应阈值较低，植入耳蜗中的SGN密度较高（p<0.05）。PPy/pTS/NT 3不会加剧纤维组织形成，也不会影响电极阻抗。耳蜗植入电极上的药物洗脱导电聚合物涂层提供了一种临床上可行的方法，以促进SGN的保存，而不会对耳蜗植入的功能产生不利影响。
Sensorineural hearing loss is associated with gradual degeneration of spiral ganglion neurons (SGNs), compromising hearing outcomes with cochlear implant use. Combination of neurotrophin delivery to the cochlea and electrical stimulation from a cochlear implant protects SGNs, prompting research into neurotrophin-eluting polymer electrode coatings. The electrically conducting polypyrrole/para-toluene sulfonate containing neurotrophin-3 (Ppy/pTS/NT3) was applied to 1.7 mm2 cochlear implant electrodes. Ppy/pTS/NT3-coated electrode arrays stored 2 ng NT3 and released 0.1 ng/day with electrical stimulation. Guinea pigs were implanted with Ppy/pTS or Ppy/pTS/NT3 electrode arrays two weeks after deafening via aminoglycosides. The electrodes of a subgroup of these guinea pigs were electrically stimulated for 8 hr/day for 2 weeks. There was a loss of SGNs in the implanted cochleae of guinea pigs with Ppy/pTS-coated electrodes indicative of electrode insertion damage. However, guinea pigs implanted with electrically stimulated Ppy/pTS/NT3-coated electrodes had lower electrically-evoked auditory brainstem response thresholds and greater SGN densities in implanted cochleae compared to non-implanted cochleae and compared to animals implanted with Ppy/pTS-coated electrodes (p<0.05). Ppy/pTS/NT3 did not exacerbate fibrous tissue formation and did not affect electrode impedance. Drug-eluting conducting polymer coatings on cochlear implant electrodes present a clinically viable method to promote preservation of SGNs without adversely affecting the function of the cochlear implant.
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发表时间：
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