A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress-induced bone loss.
A GABAergic neural circuit in the ventromedial hypothalamus mediates chronic stress-induced bone loss.
复制标题
下丘脑腹内侧的 GABA 能神经回路介导慢性应激引起的骨质流失。
DOI：
10.1172/jci136105
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发表时间：
2020-09
影响因子：
15.9
通讯作者：
Wang Liping
中科院分区：
文献类型：
--
作者：
Yang Fan;Liu Yunhui;Chen Shanping;Dai Zhongquan;Yang Dazhi;Gao Dashuang;Shao Jie;Wang Yuyao;Wang Ting;Zhang Zhijian;Zhang Lu;Lu William W;Li Yinghui;Wang Liping
骨代谢的稳态受中枢神经系统调节，焦虑等情绪障碍与骨代谢异常相关，但我们对调节骨代谢的中枢神经回路的了解有限。在这里，我们证明了在模拟空间站的孤立栖息地中，机组人员的慢性压力导致骨密度降低和焦虑升高。然后，我们使用小鼠模型来证明下丘脑腹内侧（VMH）中的GABA能神经回路介导慢性应激诱导的骨丢失。我们发现，GABA能输入VMHDM中产生的一组特定的生长抑素神经元的终纹床核（BNST），这是必不可少的应力引起的骨丢失，并能够触发骨丢失的情况下，应力。此外，交感神经系统和孤束核（NTS）内的交感神经能神经元也参与了应激性骨丢失的调节。因此，我们的研究确定了慢性应激诱导的情绪障碍（如焦虑）影响骨代谢的中枢神经机制。
Homeostasis of bone metabolism is regulated by the central nervous system and mood disorders such as anxiety are associated with bone metabolism abnormalities, yet our understanding of the central neural circuits regulating bone metabolism is limited. Here, we demonstrate that chronic stress in crewmembers resulted in decreased bone density and elevated anxiety in an isolated habitat mimicking a space station. We then used a mouse model to demonstrate that GABAergic neural circuitry in the ventromedial hypothalamus (VMH) mediates chronic stress-induced bone loss. We show that GABAergic inputs in the VMHdm arise from a specific group of somatostatin neurons in the posterior region of bed nucleus of the stria terminalis (BNST), which is indispensable for stress-induced bone loss and is able to trigger bone loss in the absence of stressors. In addition, the sympathetic system and glutamatergic neurons in nucleus tractus solitaries (NTS) were employed to regulate stress-induced bone loss. Our study has therefore identified the central neural mechanism by which chronic stress induced mood disorders, such as anxiety, influence bone metabolism.
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影响因子：
16.2
作者：
Dhillon, H;Zigman, JM;Lowelll, BB
通讯作者：
Lowelll, BB
生长抑素，神经元脆弱性和行为情绪。
影响因子：
11
作者：
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通讯作者：
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作者：
Silva, Bianca A.;Mattucci, Camilla;Krzywkowski, Piotr;Murana, Emanuele;Illarionova, Anna;Grinevich, Valery;Canteras, Newton S.;Ragozzino, Davide;Gross, Cornelius T.
通讯作者：
Gross, Cornelius T.
影响因子：
64.8
作者：
通讯作者：
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影响因子：
64.5
作者：
Yadav VK;Oury F;Suda N;Liu ZW;Gao XB;Confavreux C;Klemenhagen KC;Tanaka KF;Gingrich JA;Guo XE;Tecott LH;Mann JJ;Hen R;Horvath TL;Karsenty G
通讯作者：
Karsenty G