Survival after bone metastasis by primary cancer type: a Danish population-based cohort study.
Survival after bone metastasis by primary cancer type: a Danish population-based cohort study.
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DOI：
10.1136/bmjopen-2017-016022
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发表时间：
2017-09-11
期刊：
影响因子：
2.9
通讯作者：
Sørensen HT
中科院分区：
文献类型：
--
作者：
Svensson E;Christiansen CF;Ulrichsen SP;Rørth MR;Sørensen HT
在10种最常见的原发性骨转移类型中，我们的目的是检查生存率，进一步对骨转移或其他同步转移进行分层。我们纳入了1994年至2010年期间医院诊断为实体癌，随后诊断为BM的所有18岁及以上患者，直至2012年。我们对患者进行了随访，从骨转移诊断之日起直至死亡、移民或2012年12月31日，以先发生者为准。我们计算了1年、3年和5年生存率（%）以及根据原发癌类型分层的相应95% CI。比较仅骨转移患者和其他同步转移患者，我们估计了死亡率的粗HR和校正HR以及相应的95% CI。我们纳入了17251例骨转移患者。最常见的骨转移原发癌类型为前列腺癌（34%）、乳腺癌（22%）和肺癌（20%）。肺癌患者骨转移诊断后的一年生存率最低（10%，95% CI 9%-11%），乳腺癌患者最高（51%，50%-53%）。在5年的随访中，只有乳腺癌患者的生存率超过10%（13%，11%至14%）。除了宫颈癌、卵巢癌和膀胱癌外，与仅骨转移患者相比，大多数骨转移和同步转移癌症患者的死亡风险增加（校正相对风险1.29-1.57）。虽然大多数原发性癌症骨转移患者的生存率很低，但乳腺癌骨转移的10例患者中有1例存活了5年。
In the 10 most common primary types with bone metastases, we aimed to examine survival, further stratifying on bone metastases only or with additional synchronous metastases. We included all patients aged 18 years and older with incident hospital diagnosis of solid cancer between 1994 and 2010, subsequently diagnosed with BM until 2012. We followed patients from date of bone metastasis diagnosis until death, emigration or 31 December 2012, whichever came first. We computed 1-year, 3-year and 5-year survival (%) and the corresponding 95% CIs stratified on primary cancer type. Comparing patients with bone metastasis only and patients with other synchronous metastases, we estimated crude and adjusted HRs and corresponding 95% CI for mortality. We included 17 251 patients with bone metastasis. The most common primary cancer types with bone metastasis were prostate (34%), breast (22%) and lung (20%). One-year survival after bone metastasis diagnosis was lowest in patients with lung cancer (10%, 95% CI 9% to 11%) and highest in patients with breast cancer (51%, 50% to 53%). At 5 years of follow-up, only patients with breast cancer had over 10% survival (13%, 11% to 14%). The risk of mortality was increased for the majority of cancer types among patients with bone and synchronous metastases compared with bone only (adjusted relative risk 1.29–1.57), except for cervix, ovarian and bladder cancer. While patients with bone metastases after most primary cancers have poor survival, one of ten patients with bone metastasis from breast cancer survived 5 years.
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影响因子：
4
作者：
Thygesen SK;Christiansen CF;Christensen S;Lash TL;Sørensen HT
通讯作者：
Sørensen HT
影响因子：
3.9
作者：
Svendsen ML;Gammelager H;Sværke C;Yong M;Chia VM;Christiansen CF;Fryzek JP
通讯作者：
Fryzek JP
影响因子：
2.9
作者：
Cetin K;Christiansen CF;Sværke C;Jacobsen JB;Sørensen HT
通讯作者：
Sørensen HT
影响因子：
3.7
作者：
Santini D;Procopio G;Porta C;Ibrahim T;Barni S;Mazzara C;Fontana A;Berruti A;Berardi R;Vincenzi B;Ortega C;Ottaviani D;Carteni G;Lanzetta G;Virzì V;Santoni M;Silvestris N;Satolli MA;Collovà E;Russo A;Badalamenti G;Fedeli SL;Tanca FM;Adamo V;Maiello E;Sabbatini R;Felici A;Cinieri S;Tonini G;Bracarda S
通讯作者：
Bracarda S
影响因子：
11.5
作者：
Coleman, Robert E.
通讯作者：
Coleman, Robert E.