Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease.
Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease.
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DOI：
10.1101/cshperspect.a029314
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发表时间：
2018-01-02
影响因子：
7.2
通讯作者：
Turner JR
中科院分区：
文献类型：
--
作者：
Buckley A;Turner JR
粘膜表面排列着上皮细胞。在肠道中，上皮建立了一个选择性渗透屏障，支持营养吸收和废物分泌，同时防止肠道物质的侵入。因此，肠上皮在调节粘膜免疫系统和肠道内容物（包括膳食抗原、多种肠道微生物群和病原体）之间的相互作用中起着核心作用。细胞旁空间由紧密连接密封，紧密连接由复杂的蛋白质相互作用网络维持。紧密连接功能障碍与多种局部和全身性疾病有关。两种分子和生物物理上截然不同的途径通过肠道紧密连接受到炎症刺激的选择性和差异性调节。这篇综述讨论了这些事件背后的机制，它们对疾病的影响，以及利用这些作为发展紧密连接靶向治疗干预的范例的潜力。
Mucosal surfaces are lined by epithelial cells. In the intestine, the epithelium establishes a selectively permeable barrier that supports nutrient absorption and waste secretion while preventing intrusion by luminal materials. Intestinal epithelia therefore play a central role in regulating interactions between the mucosal immune system and luminal contents, which include dietary antigens, a diverse intestinal microbiome, and pathogens. The paracellular space is sealed by the tight junction, which is maintained by a complex network of protein interactions. Tight junction dysfunction has been linked to a variety of local and systemic diseases. Two molecularly and biophysically distinct pathways across the intestinal tight junction are selectively and differentially regulated by inflammatory stimuli. This review discusses the mechanisms underlying these events, their impact on disease, and the potential of using these as paradigms for development of tight junction-targeted therapeutic interventions.
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影响因子：
7.8
作者：
Furuse, Mikio;Hata, Masaki;Furuse, Kyoko;Yoshida, Yoko;Haratake, Akinori;Sugitani, Yoshinobu;Noda, Tetsuo;Kubo, Akiharu;Tsukita, Shoichiro
通讯作者：
Tsukita, Shoichiro
影响因子：
5.5
作者：
Colegio, OR;Van Itallie, C;Anderson, JM
通讯作者：
Anderson, JM
影响因子：
2.4
作者：
CLAUDE, P
通讯作者：
CLAUDE, P
影响因子：
64.5
作者：
Chung H;Pamp SJ;Hill JA;Surana NK;Edelman SM;Troy EB;Reading NC;Villablanca EJ;Wang S;Mora JR;Umesaki Y;Mathis D;Benoist C;Relman DA;Kasper DL
通讯作者：
Kasper DL
影响因子：
7.2
作者：
Anderson, James M.;Van Itallie, Christina M.
通讯作者：
Van Itallie, Christina M.