BALB and kirsten murine sarcoma viruses alter growth and differentiation of EGF-dependent BALB/c mouse epidermal keratinocyte lines
BALB and kirsten murine sarcoma viruses alter growth and differentiation of EGF-dependent BALB/c mouse epidermal keratinocyte lines
复制标题
BALB 和 Kirsten 鼠肉瘤病毒改变 EGF 依赖性 BALB/c 小鼠表皮角质形成细胞系的生长和分化
DOI：
10.1016/0092-8674(83)90479-8
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发表时间：
1983
期刊：
影响因子：
64.5
通讯作者：
S. Aaronson
中科院分区：
文献类型：
--
作者：
B. Weissman;S. Aaronson
Clonal BALB/c mouse epidermal keratinocyte (BALB/MK) cell lines were established in tissue culture. Despite their aneuploid nature, the lines were nontumorigenic, and retained in vitro properties similar to those of primary diploid keratinocytes. These included the constitutive expression of keratin and terminal differentiation in response to a calcium concentration greater than 1. O mM in the medium. The cells also demonstrated an absolute requirement for nanomolar concentrations of epidermal growth factor (EGF) for their proliferation. BALB or Kirsten murine sarcoma viruses are acute transforming retroviruses, which have been shown to transform fibroblastic and hematopoietic cells. Infection of BALB/MK or its clonal sublines with either virus leads to the rapid acquisition of EGF-independent growth. The cells concomitantly lose their sensitivity to calcium-induced terminal differentiation. Thus these retroviruses can rapidly confer upon epithelial keratinocytes in culture growth properties that resemble those of malignant epidermoid carcinoma cells.
转化禽RNA肿瘤病毒对禽巨噬细胞的不同影响。
DOI：
10.1073/pnas.78.6.3600
发表时间：
1981
影响因子：
11.1
作者：
Durban,EM;Boettiger,D
通讯作者：
Boettiger,D