Circadian rhythms affect bone reconstruction by regulating bone energy metabolism.
Circadian rhythms affect bone reconstruction by regulating bone energy metabolism.
复制标题
DOI：
10.1186/s12967-021-03068-x
复制
发表时间：
2021-09-27
影响因子：
7.4
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Luo B;Zhou X;Tang Q;Yin Y;Feng G;Li S;Chen L
代谢是最复杂的细胞生化反应之一，为细胞生长和增殖等基本活动提供能量和物质。早期的研究表明，葡萄糖是成骨细胞的重要营养物质。此外，氨基酸代谢和脂肪代谢在骨重建中也起着重要作用。哺乳动物的生物钟调节着各种生理功能的昼夜周期。在脊椎动物中，昼夜节律是由一组中枢时钟基因介导的：肌肉和大脑ARNT like-1 （Bmal1）、肌肉和大脑ARNT like-2 （Bmal2）、昼夜节律运动输出周期停滞（clock）、隐色素1 （Cry1）、隐色素2 （Cry2）、第1周期（Per1）、第2周期（Per2）、第3周期（Per3）和神经元PAS结构域蛋白2 （Npas2）。在转录和翻译后水平上控制的负反馈回路以昼夜的方式调节这些时钟基因。根据几种组织的昼夜节律转录组学研究结果，大多数节律基因以组织特异性的方式表达，并受组织特异性昼夜节律的影响。昼夜节律调节多种活动，包括能量代谢、进食时间、睡眠、内分泌和免疫功能。据报道，哺乳动物的昼夜节律与骨代谢密切相关。本文就成骨细胞/破骨细胞的昼夜节律/生物钟基因与骨能量代谢的调控，以及昼夜节律、骨重塑和能量代谢之间的关系作一综述。我们还讨论了调节昼夜节律或改变能量代谢对骨发育/骨再生的治疗潜力。
Metabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth and proliferation. Early studies have shown that glucose is an important nutrient in osteoblasts. In addition, amino acid metabolism and fat metabolism also play important roles in bone reconstruction. Mammalian circadian clocks regulate the circadian cycles of various physiological functions. In vertebrates, circadian rhythms are mediated by a set of central clock genes: muscle and brain ARNT like-1 (Bmal1), muscle and brain ARNT like-2 (Bmal2), circadian rhythmic motion output cycle stagnates (Clock), cryptochrome 1 (Cry1), cryptochrome2 (Cry2), period 1 (Per1), period 2 (Per2), period 3 (Per3) and neuronal PAS domain protein 2 (Npas2). Negative feedback loops, controlled at both the transcriptional and posttranslational levels, adjust these clock genes in a diurnal manner. According to the results of studies on circadian transcriptomic studies in several tissues, most rhythmic genes are expressed in a tissue-specific manner and are affected by tissue-specific circadian rhythms. The circadian rhythm regulates several activities, including energy metabolism, feeding time, sleeping, and endocrine and immune functions. It has been reported that the circadian rhythms of mammals are closely related to bone metabolism. In this review, we discuss the regulation of the circadian rhythm/circadian clock gene in osteoblasts/osteoclasts and the energy metabolism of bone, and the relationship between circadian rhythm, bone remodeling, and energy metabolism. We also discuss the therapeutic potential of regulating circadian rhythms or changing energy metabolism on bone development/bone regeneration.
登录
查看更多内容
影响因子：
7
作者：
Akagi R;Akatsu Y;Fisch KM;Alvarez-Garcia O;Teramura T;Muramatsu Y;Saito M;Sasho T;Su AI;Lotz MK
通讯作者：
Lotz MK
影响因子：
3.6
作者：
Caffarelli C;Alessi C;Nuti R;Gonnelli S
通讯作者：
Gonnelli S
影响因子：
9.2
作者：
Akhtar, RA;Reddy, AB;Kyriacou, CP
通讯作者：
Kyriacou, CP
DOI：
10.1073/pnas.1014523107
发表时间：
2010-11-02
影响因子：
11.1
作者：
Andrews, Jessica L.;Zhang, Xiping;Esser, Karyn A.
通讯作者：
Esser, Karyn A.
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS