The multifaceted mechanisms of malignant glioblastoma progression and clinical implications.
The multifaceted mechanisms of malignant glioblastoma progression and clinical implications.
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DOI：
10.1007/s10555-022-10051-5
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发表时间：
2022-12
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随着高通量测序技术在单细胞分辨率的应用，对胶质母细胞瘤的肿瘤微环境的研究揭示了巨大的细胞和组织异质性。胶质母细胞瘤是所有癌症中最具侵袭性和侵袭性的肿瘤之一。一种独特的细胞外支架系统适应并支持肿瘤细胞的渐进性渗透和迁移，其特征是成分、效应器输送和机械性能发生变化。恶性细胞和免疫细胞之间的时空相互作用产生了免疫抑制微环境，导致有效的抗肿瘤免疫攻击失败。在胶质母细胞瘤的异质性肿瘤细胞亚群中，胶质瘤干细胞(GSCs)具有很强的致瘤性和侵袭性，对肿瘤的生长至关重要，被认为与肿瘤的治疗耐药和肿瘤复发有关。在这里，我们讨论了细胞外基质和免疫细胞群在胶质母细胞瘤中的作用，以及调节GSC维持和侵袭的信号通路。我们还强调了在这些成分的治疗靶向方面的新进展。
With the application of high throughput sequencing technologies at single-cell resolution, studies of the tumor microenvironment in glioblastoma, one of the most aggressive and invasive of all cancers, have revealed immense cellular and tissue heterogeneity. A unique extracellular scaffold system adapts to and supports progressive infiltration and migration of tumor cells, which is characterized by altered composition, effector delivery, and mechanical properties. The spatiotemporal interactions between malignant and immune cells generate an immunosuppressive microenvironment, contributing to the failure of effective anti-tumor immune attack. Among the heterogeneous tumor cell subpopulations of glioblastoma, glioma stem cells (GSCs), which exhibit tumorigenic properties and strong invasive capacity, are critical for tumor growth and are believed to contribute to therapeutic resistance and tumor recurrence. Here we discuss the role of extracellular matrix and immune cell populations, major components of the tumor ecosystem in glioblastoma, as well as signaling pathways that regulate GSC maintenance and invasion. We also highlight emerging advances in therapeutic targeting of these components.
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DOI：
10.1126/science.aao4227
发表时间：
2018-09-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Albrengues J;Shields MA;Ng D;Park CG;Ambrico A;Poindexter ME;Upadhyay P;Uyeminami DL;Pommier A;Küttner V;Bružas E;Maiorino L;Bautista C;Carmona EM;Gimotty PA;Fearon DT;Chang K;Lyons SK;Pinkerton KE;Trotman LC;Goldberg MS;Yeh JT;Egeblad M
通讯作者：
Egeblad M
影响因子：
--
作者：
Bertaut A;Truntzer C;Madkouri R;Kaderbhai CG;Derangère V;Vincent J;Chauffert B;Aubriot-Lorton MH;Farah W;Mourier KL;Boidot R;Ghiringhelli F
通讯作者：
Ghiringhelli F
影响因子：
16.6
作者：
Bellail, Anita C.;Olson, Jeffrey J.;Hao, Chunhai
通讯作者：
Hao, Chunhai
影响因子：
17.1
作者：
Allen E;Jabouille A;Rivera LB;Lodewijckx I;Missiaen R;Steri V;Feyen K;Tawney J;Hanahan D;Michael IP;Bergers G
通讯作者：
Bergers G
影响因子：
2.6
作者：
Akintola, Oluwatosin O.;Reardon, David A.
通讯作者：
Reardon, David A.