Ischemic stroke in 455 COVID-19 patients.
Ischemic stroke in 455 COVID-19 patients.
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DOI：
10.1016/j.clinsp.2022.100012
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Fiorini AC
中科院分区：
文献类型：
--
作者：
Finsterer J;Scorza FA;Scorza CA;Fiorini AC
COVID-19的缺血性中风是多因素的，但主要是栓塞性的。COVID-19患者的缺血性卒中主要影响男性和前循环。自大流行爆发以来，缺血性中风的频率没有增加。越来越多的证据表明，COVID-19可能与缺血性卒中（COVID-stroke）有关。然而，covid - 19中风的频率和发病机制在很大程度上仍然未知。本叙述性综述旨在总结和讨论从文献中收集的455例新冠肺炎卒中患者的发病频率和发病机制。covid - 19卒中发生在所有年龄组，主要发生在男性中。前循环比后循环更容易受到影响。covid - 19中风最常见的是栓塞性。新冠肺炎中风的严重程度从NIHSS 3到32。心血管危险因素在covid - 19卒中患者中非常普遍。covid - 19卒中与肺部表现同时发生或最多40天后发生。COVID-19的临床表现通常很轻微，甚至没有。大多数covid - 19卒中患者实现了完全或部分康复，但四分之一的患者的结局是致命的。综上所述，自SARS-CoV-2大流行爆发以来，缺血性卒中的频率并未增加。冠状病毒中风主要影响男性和前循环。covid - 19卒中是多因素的，但主要是栓塞性的，更常归因于心血管危险因素，而不是凝血功能障碍。
Ischemic stroke in COVID-19 is multifactorial but predominantly embolic. Ischemic stroke in COVID-19 predominantly affects males and the anterior circulation. Frequency of ischemic stroke has not increased since the outbreak of the pandemic. There is increasing evidence that COVID-19 can be associated with ischemic stroke (COVID-stroke). The frequency and pathogenesis of COVID-stroke, however, remains largely unknown. This narrative review aimed at summarizing and discussing current knowledge about frequency and pathogenesis of COVID-stroke in 455 patients collected from the literature. COVID-stroke occurs in all age groups and predominantly in males. The anterior circulation is more frequently affected than the posterior circulation. COVID-stroke is most frequently embolic. The severity of COVID-stroke ranges from NIHSS 3 to 32. Cardiovascular risk factors are highly prevalent in patients with COVID-stroke. COVID-stroke occurs simultaneously with the onset of pulmonary manifestations or up to 40 days later. Clinical manifestations of COVID-19 are most frequently mild or even absent. The majority of patients with COVID-stroke achieve complete or partial recovery, but in one-quarter of patients, the outcome is fatal. In conclusion, the frequency of ischemic stroke has not increased since the outbreak of the SARS-CoV-2 pandemic. COVID-stroke predominantly affects males and the anterior circulation. COVID-stroke is multifactorial but predominantly embolic and more frequently attributable to cardiovascular risk factors than to coagulopathy.
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