Unfractionated Heparin in SARS-CoV-2 Pneumonia: Ischemic Stroke Case Report.
Unfractionated Heparin in SARS-CoV-2 Pneumonia: Ischemic Stroke Case Report.
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DOI：
10.3389/fneur.2020.573356
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发表时间：
2020
影响因子：
3.4
通讯作者：
Davies GA
中科院分区：
文献类型：
--
作者：
Efendizade A;Dmytriw AA;Hewitt K;Davies GA
血栓栓塞是2019冠状病毒病（COVID-19）患者的一种已知现象。最近的调查显示，很大一部分因严重COVID-19住院的患者表现出与高凝相容的临床和实验室标志物，高凝性与弥散性血管内凝血（DIC）不同，称为COVID-19相关凝血病。此外，由于这种高凝状态，人们越来越关注急性缺血性卒中的发展。我们报告了一名COVID-19肺炎患者，他接受了未分割肝素（UFH）输注治疗，并在输注停止后不久发生了大面积缺血性梗死。回想起来，患者的凝血参数与显性DIC一致，尽管其中一些参数很容易被UFH的影响所掩盖。这些发现强调了抗凝治疗的重要性以及谨慎停用抗凝治疗的重要性，因为不这样做可能会导致严重的血栓栓塞事件。
Thromboembolism is a known phenomenon in patients with Coronavirus disease 2019 (COVID-19). Recent investigations have revealed that a significant proportion of those hospitalized with severe COVID-19 demonstrate clinical and laboratory markers compatible with hypercoagulability, which is differentiated from disseminated intravascular coagulation (DIC), termed COVID-associated coagulopathy. Additionally, there is increasing concern for development of acute ischemic stroke because of this hypercoagulable state. We present a patient with COVID-19 pneumonia who was managed with unfractionated heparin (UFH) infusion and developed a large ischemic infarct shortly after cessation of the infusion. In retrospect, the patient's coagulation parameters were consistent with overt DIC, although some of these parameters are easily masked by the effects of UFH. These findings emphasize the importance of anticoagulation as well as its careful discontinuation, as failure to do so may result in a significant thromboembolic event.
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DOI：
10.1111/jth.14817
发表时间：
2020-05
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
通讯作者：
--
影响因子：
10.4
作者：
Cui, Songping;Chen, Shuo;Wang, Feng
通讯作者：
Wang, Feng
影响因子：
10.4
作者：
Tang, Ning;Li, Dengju;Sun, Ziyong
通讯作者：
Sun, Ziyong
影响因子：
7.1
作者：
Wada H;Matsumoto T;Yamashita Y
通讯作者：
Yamashita Y
影响因子：
168.9
作者：
Chen, Nanshan;Zhou, Min;Zhang, Li
通讯作者：
Zhang, Li