mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.
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DOI：
10.1038/s42003-022-03765-3
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发表时间：
2022-08-06
影响因子：
5.9
通讯作者：
Dowling, David J.
中科院分区：
文献类型：
--
作者：
Nanishi, Etsuro;McGrath, Marisa E.;O'Meara, Timothy R.;Barman, Soumik;Yu, Jingyou;Wan, Huahua;Dillen, Carly A.;Menon, Manisha;Seo, Hyuk-Soo;Song, Kijun;Xu, Andrew Z.;Sebastian, Luke;Brook, Byron;Bosco, Anna-Nicole;Borriello, Francesco;Ernst, Robert K.;Barouch, Dan H.;Dhe-Paganon, Sirano;Levy, Ofer;Frieman, Matthew B.;Dowling, David J.
SARS-CoV-2组粒变体逃避疫苗诱导的免疫。虽然加强剂量的祖传mRNA疫苗可以有效地引发针对变异的中和抗体，但其对老年人（患严重疾病的风险最大）的抗Omicron效果尚未完全阐明。在这里，我们评估了mRNA BNT162b2的多个纵向免疫方案，以评估在初次免疫系列后8个月提供的加强剂量在整个小鼠生命周期中的效果，包括21月龄小鼠。增强显著增强体液和细胞介导的反应与证据的染色体克隆交叉识别。此外，虽然年轻的小鼠在没有增强剂的情况下受到保护，但增强剂可以为21个月大的小鼠提供针对欧米克隆诱导的肺部感染的绝育免疫。相关分析显示，对Omicron的中和活性与保护作用密切相关。总体而言，我们的研究结果表明了年龄依赖性疫苗的有效性，并证明了mRNA增强免疫在保护脆弱的老年人群免受SARS-CoV-2变体侵害方面的潜在益处。一项小鼠纵向研究表明，mRNA疫苗BNT162b2加强剂量可增强体液和细胞介导的应答，并对老年动物omicron诱导的肺部感染提供灭菌免疫。
The SARS-CoV-2 Omicron variant evades vaccine-induced immunity. While a booster dose of ancestral mRNA vaccines effectively elicits neutralizing antibodies against variants, its efficacy against Omicron in older adults, who are at the greatest risk of severe disease, is not fully elucidated. Here, we evaluate multiple longitudinal immunization regimens of mRNA BNT162b2 to assess the effects of a booster dose provided >8 months after the primary immunization series across the murine lifespan, including in aged 21-month-old mice. Boosting dramatically enhances humoral and cell-mediated responses with evidence of Omicron cross-recognition. Furthermore, while younger mice are protected without a booster dose, boosting provides sterilizing immunity against Omicron-induced lung infection in aged 21-month-old mice. Correlational analyses reveal that neutralizing activity against Omicron is strongly associated with protection. Overall, our findings indicate age-dependent vaccine efficacy and demonstrate the potential benefit of mRNA booster immunization to protect vulnerable older populations against SARS-CoV-2 variants. A longitudinal study in mice reveals that a booster dose of mRNA vaccine BNT162b2 enhances humoral and cell-mediated responses and provides sterilizing immunity against Omicron-induced lung infection in aged animals.
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BNT162B2 mRNA COVID-19疫苗的安全性和功效。
DOI：
10.1056/nejmoa2034577
发表时间：
2020-12-31
期刊：
The New England journal of medicine
影响因子：
--
作者：
Polack FP;Thomas SJ;Kitchin N;Absalon J;Gurtman A;Lockhart S;Perez JL;Pérez Marc G;Moreira ED;Zerbini C;Bailey R;Swanson KA;Roychoudhury S;Koury K;Li P;Kalina WV;Cooper D;Frenck RW Jr;Hammitt LL;Türeci Ö;Nell H;Schaefer A;Ünal S;Tresnan DB;Mather S;Dormitzer PR;Şahin U;Jansen KU;Gruber WC;C4591001 Clinical Trial Group
通讯作者：
C4591001 Clinical Trial Group
DOI：
10.1126/science.abm0620
发表时间：
2022-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
通讯作者：
--
影响因子：
82.9
作者：
Gruell H;Vanshylla K;Tober-Lau P;Hillus D;Schommers P;Lehmann C;Kurth F;Sander LE;Klein F
通讯作者：
Klein F
影响因子：
82.9
作者：
Andrews, Nick;Stowe, Julia;Kirsebom, Freja;Toffa, Samuel;Sachdeva, Ruchira;Gower, Charlotte;Ramsay, Mary;Bernal, Jamie Lopez
通讯作者：
Bernal, Jamie Lopez
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group