Influence of pregnancy on parathion toxicity and disposition.
Influence of pregnancy on parathion toxicity and disposition.
复制标题
妊娠对硫磷毒性和处置的影响。
DOI：
10.1016/0041-008x(83)90338-1
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发表时间：
1983
影响因子：
3.8
通讯作者：
J. Lech
中科院分区：
文献类型：
--
作者：
S. Weitman;M. Vodicnik;J. Lech
研究了妊娠和哺乳期对硫磷和对氧磷的毒性和分布的影响。服用对硫磷或其活性代谢物对氧磷后，与未交配的对照组相比，怀孕小鼠的胆碱能刺激症状更为强烈。在妊娠 19 天或产后第 19 天给予单剂量 5 mg/kg 对硫磷或 0.58 mg/kg 对氧磷后，测定小鼠的胆碱酯酶活性和对硫磷和对氧磷的组织水平。接受治疗的怀孕小鼠的血浆（伪）胆碱酯酶活性始终较低。与接受类似处理的处女动物相比，用对硫磷或对氧磷治疗后，怀孕小鼠的总脑胆碱酯酶也受到更大程度的抑制。此外，当对怀孕和未交配动物给予等量的对氧磷（32μg）时，怀孕小鼠的总脑胆碱酯酶显着降低。与处女小鼠相比，在产后第 19 天给哺乳小鼠施用对硫磷并没有导致血浆或脑胆碱酯酶活性出现任何显着差异。用 5 mg/kg 对硫磷处理的怀孕小鼠的血液和大脑中对硫磷和对氧磷的浓度高于接受类似处理的处女对照，这与增强的胆碱酯酶抑制相关。怀孕期间血清对氧磷酶活性显着降低也证明了对氧磷解毒能力的下降。
The effects of pregnancy and lactation on the toxicity and distribution of parathion and paraoxon were examined. Signs of cholinergic stimulation were more intense in pregnant mice when compared to virgin controls after administration of parathion or its active metabolite, paraoxon. Cholinesterase activity and tissue levels of parathion and paraoxon were determined in mice at 19 days of gestation or Day 19 postpartum after administration of a single dose of 5 mg/kg parathion or 0.58 mg/kg paraoxon. Plasma (pseudo) cholinesterase activity was consistently lower in treated pregnant mice. Total brain cholinesterase was also suppressed to a greater degree in pregnant mice after treatment with parathion or paraoxon when compared with virgin animals treated similarly. In addition, when equal quantities of paraoxon (32 μg) were administered to both pregnant and virgin animals, total brain cholinesterase was significantly less in pregnant mice. Administration of parathion to lactating mice on Day 19 postpartum did not result in any significant differences in plasma or brain cholinesterase activity when compared to that in virgin animals. Pregnant mice treated with 5 mg/kg parathion demonstrated higher concentrations of both parathion and paraoxon in blood and brain than similarly treated virgin controls which correlated with the enhanced cholinesterase inhibition. Decreased ability to detoxify paraoxon was also demonstrated by a significant reduction in serum paraoxonase activity during pregnancy.
2,4,5,2,4,5-六氯联苯向胎儿和哺乳后代的转移。
影响因子：
3.8
作者：
Vodicnik,MJ;Lech,JJ
通讯作者：
Lech,JJ
2,4,5,2,4,5-六氯联苯向胎儿和哺乳后代的转移。
影响因子：
3.8
作者：
Vodicnik,MJ;Elcombe,CR;Lech,JJ
通讯作者：
Lech,JJ