Catalase and glutathione peroxidase mimics.
Catalase and glutathione peroxidase mimics.
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DOI：
10.1016/j.bcp.2008.09.029
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发表时间：
2009-02-01
影响因子：
5.8
通讯作者：
Day BJ
中科院分区：
文献类型：
--
作者：
Day BJ
活性氧（ROS）、超氧化物（O2−）和过氧化氢（H2O2）的过度产生越来越多地与人类疾病和衰老有关。ROS也被探索为许多细胞信号通路中的重要调节剂。早期的工作集中在开发O2−的小型催化清除剂，通常称为超氧化物歧化酶（SOD）模拟物。这些化合物中的许多还具有催化氧化H2O2和过氧亚硝酸根（ONOO−）的能力。过氧化物越来越多地被证明会破坏与各种人类疾病相关的过度炎症相关的细胞信号级联。早期的酶清除剂如SOD的研究经常报告很少或没有在生物模型中的有益效果，除非SOD与过氧化氢酶或过氧化物酶相结合。越来越多的注意力已经致力于开发过氧化氢酶或过氧化物酶模拟物作为治疗与许多人类疾病的病理生理学相关的明显炎症的一种方式。本文将重点介绍过氧化物催化清除剂的最新进展及其作为肺、心血管、神经退行性和炎症性疾病治疗剂的潜在用途。
Overproduction of the reactive oxygen species (ROS) superoxide (O2−) and hydrogen peroxide (H2O2) are increasingly implicated in human disease and aging. ROS are also being explored as important modulating agents in a number of cell signaling pathways. Earlier work has focused on development of small catalytic scavengers of O2−, commonly referred to as superoxide dismutase (SOD) mimetics. Many of these compounds also have substantial abilities to catalytically scavenge H2O2 and peroxynitrite (ONOO−). Peroxides have been increasingly shown to disrupt cell signaling cascades associated with excessive inflammation associated with a wide variety of human diseases. Early studies with enzymatic scavengers like SOD frequently reported little or no beneficial effect in biologic models unless SOD was combined with catalase or a peroxidase. Increasing attention has been devoted to developing catalase or peroxidase mimetics as a way to treat overt inflammation associated with the pathophysiology of many human disorders. This review will focus on recent development of catalytic scavengers of peroxides and their potential use as therapeutic agents for pulmonary, cardiovascular, neurodegenerative and inflammatory disorders.
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影响因子：
5.8
作者：
COTGREAVE, IA;DUDDY, SK;MOLDEUS, P
通讯作者：
MOLDEUS, P
影响因子：
24
作者：
Blum, Shany;Asaf, Roy;Levy, Andrew P.
通讯作者：
Levy, Andrew P.
影响因子：
3.9
作者：
Day, BJ;Fridovich, I;Crapo, JD
通讯作者：
Crapo, JD
影响因子：
7.4
作者：
Day, BJ;Batinic-Haberle, I;Crapo, JD
通讯作者：
Crapo, JD
DOI：
10.1152/ajplung.00191.2002
发表时间：
2003-04-01
影响因子：
4.9
作者：
Bowler, RP;Arcaroli, J;Crapo, JD
通讯作者：
Crapo, JD